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Provides single point of contact for Harvard researchers interested in bioinformatics support, applying genomic approaches together with established and developing methodologies from epidemiology, environmental health, biostatistics and bioinformatics to improve human health.Services include analysis all types of next-generation sequencing data from RNA-seq and single cell RNA-seq to variant sequencing (exome or whole genome), to ChIP-seq or bisulfite sequencing. Offers bioinformatics training program for Harvard researchers interested in learning basic data skills and analysis of high-throughput sequencing data.
Software application as coverage-guided approach for scalable construction of read overlapping graph. Used to handle numbers of datasets from large genomes, especially with limited computational resources.
Fully automated cell counter and assay platform that uses optics and image analysis algorithms to analyze trypan blue-stained cells in suspension. Benchtop device that measures cell concentration and viability.
Compact, personal UV-Vis microvolume spectrophotometer that complements the full-featured NanoDrop 2000/2000c and NanoDrop 8000 instruments.
Markerless video-based tool to simultaneously track two interacting mice of the same appearance in controlled settings for quantifying behaviors such as different types of sniffing, touching, and locomotion to improve tracking accuracy under these settings without increased human effort. It incorporates conventional handcrafted tracking and deep-learning-based techniques. The tool is trained on small number of manually annotated images from basic experimental setup and outputs body masks and coordinates of the snout and tail-base for each mouse.
Software for analysis to determine live versus dead cells – no fluorescent dyes needed.
Web tool for identification and characterization of channels in transmembrane proteins from their three-dimensional structure.
Provides catalogue of confirmed and predicted DNA replication origin sites. At present this is limited to budding yeast and fission yeast. Data have been collated as culmination of number of genome-wide studies to identify location of replication origins throughout budding yeast genome. In addition to genome-wide studies data from large number of other origin mapping and characterization studies have been included.
Provides cytometry services featuring sorting and analyzing. For analysis, we currently have BD LSR Fortessa, BD FACSymphony A3, and Cytek Aurora. Our cell sorters include 14-parameter, 4-laser Sony MA900 and 16-parameter, 5-laser FACSAria dedicated to BSL3 cell sorting.
Software pipeline is set to to non-model plant GO/KO function annotations using R. It can collect data from Eggnog-mapper of custom BLAST, convert data, and make OrgDB packages.
Hillman/University of Pittsburgh co-managed ACCT Labs are cell therapy labs located in more than 15,000 sq ft of lab space, boasting 12 clean rooms. ACCT labs offer services and expertise including the manufacturing cell therapy products for cancer cell therapy trials. The labs are also responsible for monitoring immune function through cell therapy treatments and processing blood products for a number of clinical trials.
Supports analytical cytometry and cell sorting. Offers NanoString Digital Spatial Analyzer and nCounter service and support.
Provides novel quantitative imaging techniques that trace biomarkers of molecular events associated with effective cancer therapy.
Expertise resides in micro and nanotechnology, sensors, transducers, microelectromechanical systems (MEMS), advanced materials, biomedical devices, space and governmental applications.Offers SEM and TEM imaging services for biological samples.
Provides bioanalytical, pharmacokinetic and pharmacology research services that support preclinical and clinical research programs focused on oncology. Resources include HPLC-UV/fluorescence, ICP-MS, LC-MS/MS, LSC, ELISA, and in vivo rodent procedures, as well as advanced PK software suites and expertise for preclinical and clinical projects.
Supports genomics and transcriptomics platforms including nucleic acid extraction, sample QC, next-generation library preparation and sequencing. Specializes in paraffin-embedded tissue samples.
Provides bioinformatics support for translational genomics using sequencing, arrays, single cell, and other technologies.
Provides statistical and computational methods for design, execution, analysis, and reporting of cancer-related research studies and trials including biomarker analysis and grant development.
Light microscopy core facility at Newcastle University based in the Faculty of Medical Sciences, providing services, access, training and support for light microscopy.
Software tool for single cell WGS analysis. Used to accurately detect single base substitutions, insertions-deletions (indels), and structural variants in PTA-based WGS data.