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Provides optical imaging and analysis of fixed and live cells. Services include assistance with selecting imaging platform, developing customized imaging assays, training in imaging and data analysis and assistance with image/data preparation for presentations and publications. Applications include Multi-plate based imaging applications; High-resolution cell characterization and sub-cellular localization using IN cell Analyzers;3D Spheroid and Organoid imaging using a Nikon A1R BioPipeline;Live-cell analysis (confluency, growth tracking) using Incucyte - imaging within incubator.
Provides instrumentation and expertise for the automation of laboratory processes. Facility has automated screening platforms and accessory equipment to enable flexible and scalable in vitro and in vivo assays including organoids. Services include access to chemical and genome-wide siRNA libraries, assay development and implementation, and data analysis. Applications include drug discovery and lead validation; ELISA-based assays for immune surveillance; protein biomarker discovery using OLINK proteomics technology; multiplexed barcode screening assays.
Advanced imaging facility for microscopy needs where users have access to technologies in advanced microscopy.Services include consultation on experimental design, advice on appropriate systems, training and support for assisted and unassisted use, as well as help with data analysis and image generation for publications. Applications include Fluorescence and brightfield image acquisition; Whole-slide scanning; Dynamic live-cell imaging; Super-resolution imaging.
Software simulator that leverages data-driven information to set both variants and reads characteristics, producing realistic tumoral samples. Computational modelling of cancer-specific variants and sequencing reads characteristics for realistic tumoral sample simulation.
Portal provides access to technical modeling information, raw data, and publication extensions stemming from the work of the CISNET consortium to improve understanding of cancer control interventions in prevention.
Medical research institute in Toronto, Ontario and part of the Sinai Health System. It was originally established in 1985 as the Samuel Lunenfeld Research Institute, the research arm of Mount Sinai Hospital, by an endowment from the Lunenfeld and Kunin families.
Core provides both short and long read sequencing capabilities for analysis of gene function and expression.Facility specializes in functional genomics and single cell biology. Services include consultation, sample preparation (especially for spatial and single cell applications), quality control, sequencing analysis, bioinformatics support, and assistance with grant and publication writing related to the services. Applications include:gene function analysis - pooled CRISPR screening, multiplexed barcode screens; whole genome sequencing - both short- and long-read sequencing; bulk gene expression profiling; single cell biology (single cells and single nuclei); spatial profiling; pathogen detection and profiling.
Core provides flow cytometry analyzers and cell sorters, with specialty in image-based flow cytometry and cell sorting.Services include unassisted and full-service cell sorting, training on theory and on instruments, consultation on experiment design, protocol development, data analysis, manuscript preparation and grant submission. Applications include image-based analysis powered by machine learning on the Amnis ImageStream; image-based cell sorting using the BD BACS Discover S8; cell sorting for a variety of applications including multi-color sort for bulk culture, indexed cell sort into 96-well plates, cell cycle phase sort and primary tissue sorting for RNA or DNA analysis.
Core offers statistical analysis of genomics data. Provides suite of standardized analysis pipelines for common data types like RNA-seq, ATAC-seq, and genome assembly. For more complex datasets, such as single-cell genomics, provides tailored analysis solutions. Core team assists with all project stages, from experimental design to publication support and data management. GDSC hosts several multi-day bioinformatics workshops designed to introduce fundamental concepts for analysis of genomics data.
Reference atlas of the developing post-natal mouse brain. Provides data and annotations on distribution of cells and gene expression in mouse brain.
Open source hardware and software solution for flexible implementation of complex behaviors in head-fixed mice. Low cost and requires little to no programming experience. Allows neural activity to be seen during testing, which will show relations between neuronal activity and behavior during tasks such as alternative forced choice, GoNoGo, and sensory stimulus presentation.
Interactive webserver for exploratory analysis and visualisation of bacteriophage genomes.
Open-source software Python package for developing and comparing radiomics models. Used to build radiomics models and evaluate them using independent testing dataset. It also provides easy model comparison and result visualization.
Compact benchtop flow cytometer based on capillary system with HTS high throughput screening. Uses microcapillary laser based technology to detect mammalian and microbial cells, particles, and beads. System can resolve the fluorescence from up to 12 fluorophores simultaneously.
Software plugin will open new cell counter GUI in ImageJ to facilitate manual cell counting.
Provides mass-spectrometry based identification and quantification of proteins. Facility specializes in functional proteomics with focus on protein proximity and protein interaction mapping. Services include access to reagents, plasmids, sample preparation, mass spectrometry, and data analysis.Applications include: proximity-dependent biotinylation mapping to identify neighboring proteins in cells ,protein-protein interaction mapping,post-translational modification identification (with a focus on phosphorylation),differential protein abundance,chemical proteomics (identifying on- and off-target binding to small molecules or biologics)., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.
Facility consist of Philips 3.0 Tesla MRI scanner for studies on humans, Bruker small bore 9.4 Tesla MRI scanner, and computing facility for image archival and analysis. Scanners are entirely dedicated to research, and MR scanning is carried out on cost recovery basis. The scanners were selected to cater to a very broad range of in vivo applications and the Imaging Centre staff is trained to support any research projects that the scanners can accommodate.
Provides single point of contact for Harvard researchers interested in bioinformatics support, applying genomic approaches together with established and developing methodologies from epidemiology, environmental health, biostatistics and bioinformatics to improve human health.Services include analysis all types of next-generation sequencing data from RNA-seq and single cell RNA-seq to variant sequencing (exome or whole genome), to ChIP-seq or bisulfite sequencing. Offers bioinformatics training program for Harvard researchers interested in learning basic data skills and analysis of high-throughput sequencing data.
Software application as coverage-guided approach for scalable construction of read overlapping graph. Used to handle numbers of datasets from large genomes, especially with limited computational resources.
Fully automated cell counter and assay platform that uses optics and image analysis algorithms to analyze trypan blue-stained cells in suspension. Benchtop device that measures cell concentration and viability.