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Software for scientific image capture and analysis.
Core provides services and expertise in the areas of proteomics, metabolomics, small molecules, and molecular interactions. The staff can assist in data collection for experiments as well as provide help in experimental design and data analysis. Value added work such as grant writing and publication methods/figures is provided free of charge.
Offers manufacturing of cellular and biologics for safety and initial efficacy testing in first–in– human, pilot, and Phase I clinical trials. Facilitates bench–to–bed translation into novel cellular therapies. Provides focused scientific, technical, and regulatory support for investigator-initiated investigational new drug applications (INDs) in cell and gene therapy. Current and completed trials include hematologic malignancies multiple myeloma, breast cancer, prostate cancer, glioblastoma, neuroblastoma, and pancreatic cancer. The potential applications of cellular therapy and biologics are not limited to cancer, a large number of disease indications such as cardiovascular, autoimmune diseases, diabetes, neurological diseases, etc.
Promotes the expansion and enhancement of clinical research that incorporates exercise physiology and body composition into research questions. Offers measures of resting and exercise oxygen consumption, lactate threshold assessment, endothelial function, regional distribution of body fat, body composition assessment, anthropometry, and the use of acute exercise and/or exercise training as an intervention.
Core provides services to produce and preserve genetically engineered mouse strains for animal model research.Supports animal model research endeavors, to advance genetic and reproductive technologies for model creation and preservation, and to serve as resource for design, development and derivation of customized mouse strains.
Core specializes in imaging small animals and samples with variety of modalities depending on the investigator’s needs. These modalities include MRI, X-Ray CT, PET, SPECT, luminescence, and fluorescence. We work closely with the Radiochemistry Core Lab which can synthesize custom, targeted PET and SPECT imaging agents.
Provides access to high-quality novel and existing radiopharmaceuticals (radiolabeled small molecules, peptides, proteins, and antibodies), that can be imaged by Positron Emission Tomography (PET) method, to meet their preclinical and clinical needs. Radiochemistry core is Good Manufacturing Practices (cGMP) certified facility as required by the U.S. Pharmacopeia Chapter 823 and 21CFR part 212 and is BSL-2 certified facility to conduct research.
Core provides standard and customized research specific histology services including routine formalin fixation and paraffin embedding, and sectioning, automated Hematoxylin and Eosin staining as well as selection of manually prepared special stains and preparation of frozen section.
Facility has NMR spectrometers used to execute experiments typically used for structure elucidation and dynamics characterization of both small and large (ie. protein) molecules in solution. All spectrometers are connected to the internet. Data can be readily transferred for remote processing and the campus has a site license for Mestrenova NMR data processing and visualization software. Assistance is available for all who wish to use NMR spectroscopy. Advice on all aspects of solution NMR spectroscopy is available from the facility manager.
Software that can handle NMR and MS data and combines both technologies for even deeper insights and more comprehensive analysis.
Desktop app that provides no-code user interface for converting neurophysiology data to Neurodata Without Borders.
Browser-based tool designed for visualization of Neurodata Without Borders files, whether stored locally or hosted remotely, and enables interactive exploration of DANDI Archive.
Software Python-based package designed to asses quality of Neurodata Without Borders files and based on compliance with Best Practice. Meant as companion to PyNWB validator, which checks for strict schema compliance. Attempts to apply some commonsense rules and heuristics to find data components of file that pass validation, but are probably incorrect, or suboptimal, or deviate from best practices. In other words, while PyNWB validator focuses on compliance of structure of file with the schema, the inspector focuses on compliance of actual data with best practices. Meant as data review aid. It does not catch all best practice violations, and any warnings it does produce should be checked by knowledgeable reviewer.
Universal framework for describing behavioral tasks. Language to abstract and standardize behavioral task descriptions on two layers. Graphical layer specifies elements to describe behavioral tasks as state machine in formal flow diagram and how task controlling system interacts with subject. This graphical layer has been designed to be easy to understand while retaining all aspects of behavioral task. The second layer is corresponding, XML-based description of task. This layer forms rigid, yet extensible foundation of BEADL and hides hardware implementation related details form graphical representation.BEADL-specific extension for Neurodata Without Borders data standard defines how behavioral outcomes of task are stored in NWB including corresponding BEADL task description.
Instrument that runs Biolog's microplate metabolic arrays. Incubates and monitors 50 microplates, or 1,920 phenotypic assays simultaneously to measure physiological responses in diverse microbial cells. OmniLog PM system includes software for analysis of Biolog Phenotype MicroArray panels.
Automated cell counter accurately counts cells in one simple step using auto-focus technology and cell-counting algorithm. Enables accurate cell counting in less than 30 seconds.
Provides digital infrastructure, data analytics and decision support tools to help in diagnosis, treatment and monitoring of patients.
Whole body magnetic resonance imaging scanner designed to support high resolution, high signal-to-noise ratio and fast scan times. This MRI system features superconducting magnet that operates at 3. O Tesla.
Software R package for comprehensive identification of enriched pathways in omics data through active subnetworks. Uses protein interaction networks to find enriched pathways from transcriptomic data.
Project titled Program to Reveal and Evaluate Cells-to-gene Information that Specify Intricacies, Origins, and Nature of Human Pain (PRECISION) Network to develop meaningful resource for knowledge transfer, and to integrate and share Human Pain Associated Genes and Cell Datasets. Building knowledge platform to visualize, query, and interact with these data will support researchers and help accelerate dissemination of vital data to the larger scientific community. These goals align with NIH Helping to End Addiction Long-term (HEAL) Initiative, which seeks to accelerate the discovery and successful translation of non-addictive pain therapeutics. PRECISION Human Pain Network will leverage prior interdisciplinary collaboration to create workflows, tools, and infrastructure to define data and metadata types, to improve data management and sharing, and to integrate datasets and visualization tools.