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Compact, dual-channel fluorometer designed to provide highly sensitive fluorescent detection when quantifying nucleic acids. Fluorometer is optimized with preprogrammed settings for Promega QuantiFluor Dye Systems (QuantiFluor dsDNA, RNA and ssDNA Systems) to quantitate nucleic acids and offers flexibility to create customized methods and quantitation settings for other fluorescent dyes.
Website to identify the effects of certain gene mutations on splice behaviour.
Biophysical Core Facility supports structural biology studies focused on characterization of biophysical properties of biomolecules and their interactions with binding partners or novel drug candidates. Offers range of biophysical techniques for initial screening of hit/lead compound binding as well as rigorous characterization of the thermodynamic and hydrodynamic properties of various biological macromolecules (most commonly proteins and nucleic acids), macromolecular association reactions, and ligand-macromolecule interactions. Biophysical techniques include differential scanning fluorimetry, microscale thermophoresis, isothermal titration calorimetry, differential scanning calorimetry, circular dichroism spectroscopy, fluorescence spectroscopy, absorbance spectroscopy and analytical ultracentrifugation.
Amerigo Scientific collaborates closely with leading manufacturers worldwide and invites cooperation to all companies and institutions in the branch of reagents, kits, antibodies, and many other products for life science, biochemistry, and biotechnology.
Self-contained X-ray system for delivering precise radiation dosage to specimens in biological or small animal research laboratory. The shielded cabinet includes Adjustable Specimen Shelf, Sample Viewing Window and Beam Hardening Filter Holder.TouchRAD Control Panel is multi-user, password protected touch screen interface with transportable database that can track individual system usage.Passwords, programmed exposure settings, and database management are controlled by super-user.X-ray tube is used specifically for radiation therapy having highly homogenous beam. Options available include: Dose Measurement & Control, Motorized Specimen Shelf,Turntable, Fixed Beam Collimators, Adjustable Collimator, and Specimen Holding Fixtures.
Biotechnology company in Cambridge, Massachusetts, developing the next generation of genomic profiling tools that enable researchers to gain new insight into the biological systems that underlie human health and disease with spatial context. The company's MERSCOPE platform enables massively multiplexed, genome-scale nucleic acid imaging with high accuracy and unrivaled detection efficiency at subcellular resolution.
System automates sample imaging, imaging analysis, and cell segmentation, delivering high-resolution, high-throughput imaging without compromising sensitivity. Powered by MERFISH technology, MERSCOPE Ultra includes high-performance analysis computer, along with the necessary reagents and software to accurately quantify and localize RNA and protein in tissue samples. High-resolution in situ spatial genomics platform that offers tissue-wide view of up to 1000 custom genes at single-cell resolution.
Facility offers preparation and visualization ranging from standard 2D EM methods to high resolution 3D cryo-EM. Instruments, training and assisted use are available for Brandeis faculty, staff, and lab members, as well as members of the broader scientific community, including other academic institutions and for-profit organizations.
Facility provides access to and operational support for easy-to-operate equipment for sample preparation and analysis, including gel imagers, plate readers, and qPCRs. They provide training on instrument operation and grant access for independent use after completed training.
Core provides equipment, personnel, and protocols for routine and advanced cellular and molecular assays for research.
Software R package used for calling Copy Number Variations from single-cell ATAC data.
Medical image analysis software to measure, segment and analyze multi-slice scanner data.
Born of the desire to systematize analyses from The Cancer Genome Atlas pilot and scale their execution to the dozens of remaining diseases to be studied, GDAC Firehose now sits atop terabytes of analysis-ready TCGA data and reliably executes thousands of pipelines per month.
Software tool to distinguish host and graft reads from next generation sequencing assays of xenograft samples. Performs classification of xenograft-derived sequence read data.
Software Python toolkit for mutational signature analysis. Used to estimate mutational signatures from somatic mutations in genome.
Software tool for estimating genome copy numbers from high throughput DNA sequencing data. Allele-specific copy number and clonal heterogeneity analysis tool for high-throughput DNA sequencing. Used to implement Fraction and Copy number Estimate from Tumor/normal Sequencing.
Software tool for detecting somatic point mutations in high throughput DNA sequencing data of tumors. Used for modeling evolution of allelic composition of tumor and normal tissue at each reference base. Adopts sample-specific error model to depict inter-tumor heterogeneity, which greatly improves overall accuracy.
Facility offers conventional as well as molecular cytogenetic services including karyotyping, analysis of genomic instability, fluorescence in situ hybridization, telomere analysis, Spectral Karyotyping, species identification, inter-species and intra-species cell line contamination, STR fingerprinting service for cell line authentication, mycoplasma contamination testing and distribution of cell lines.
Genomics core facility with goal to use instrumentation and innovative technical expertise in order to provide investigators with genomic data from comprehensive range of genomic services in timely manner. Services include Next-Generation Sequencing, Sanger Sequencing Single Cell Sequencing, Microarray Services, Fluorescent Fragment Length Analysis, nanoString nCounter Analysis, Bionano Optical Genome Mapping, Spatial Transcriptomics, Nanopore Sequencing.
Software workflow that converts unprocessed reads into annotated binding sites using improved statistical framework. Used for analysis of CLIP-seq data and to process CLIP data from fastq files.