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DNA synthesis company provides comprehensive services including gene synthesis, protein expression, gene editing, etc., supporting one-stop solutions for global users.
Company from India specializes in Innovative Organic Chemistry and Synthesis of Unique Complex Molecules, Stable Isotope Labelled compounds and Metabolites.
Provides access and training on two FACS Calibur benchtop cytometers, one FACS Canto II multi-laser digital cytometer, one FACS Aria II cell sorter, one FACS Aria III cell sorter, and one Sony SH800 cell sorter. These systems are primarily used for the rapid analysis and sorting of single-cell suspensions. To analyze the light scatter and fluorescence characteristics of a cell population, one of the benchtop machines is appropriate. For more complex assays requiring more than four differentiating markers, then the high-end multi-laser Canto II system would work well. To rapidly retrieve or sort a particular sub-group of cells from a mixed sample, then a cell sorter would be required.
Core dedicated to the protocol driven collection, analysis, and reporting of behavioral data using a blend of classic and innovative assays. Supports neuroscience, psychology, pharmacology, genetics, cancer, and development by providing advanced tools and expertise for the precise measurement and interpretation of behavior.
Software genome completeness evaluation tool based on miniprot.
Software Python pipeline for mitochondrial genome assembly from PacBio High Fidelity reads. Used to find, circularise and annotate mitogenome from PacBio assemblies.
Standalone tool to compute assembly summary statistics and manipulate assembly sequences in FASTA, FASTQ or GFA [.gz] format. Gfastats stores assembly sequences internally in a GFA-like format. This feature allows gfastats to seamlessly convert FAST* to and from GFA [.gz] files. Gfastats can also build an assembly graph that can in turn be used to manipulate the underlying sequences following instructions provided by the user, while simultaneously generating key metrics for the new sequences.
Software Foreign Contamination Screening - GX source code. Part of NCBI’s Foreign Contamination Screen (FCS) tool suite, optimized to identify and remove contaminant sequences in new genomes.
Software application as genomic k-mer counter and sequence utility.
Fully automated patch clamp system which records from either 4 or 8 cells simultaneously. Automated electrophysiology machine.
Facility dedicated to study of degraded and low DNA yield samples, such as environmental DNA, historical DNA, or ancient DNA. Offers positive pressure lab spaces that follow strict decontamination procedures to prevent human, bacterial, and fungal contamination. It is physically isolated from tissue samples or polymerase chain reaction (PCR) products to avoid contamination from samples with higher DNA concentration and quality. The space has dedicated equipment necessary for DNA extraction and PCR-free sample preparation.
Software package implements method to deal with missing data. The package creates multiple imputations (replacement values) for multivariate missing data.Various diagnostic plots are available to inspect the quality of the imputations.
Core offers sequencing, upstream library construction (bulk RNA/DNA, single-cell), and post-sequencing analysis. Core uses Illumina NextSeq 2000 sequencers (and a MiSeq). Single-cell (fresh, frozen, FFPE) libraries (3' & 5' RNA-Seq, CITE-Seq, ATAC-Seq, Multiome, FLEX) are made with 10X Chromium X.
Offers wide range of electron microscopy (both transmission and scanning), accessory instrumentation, and expertise to the scientific and engineering community through education, collaboration, and service. Provides facilities for preparation and examination of many types of bulk and thin specimens (foils/films), fine particles, and replicas, including biological materials, by transmission and scanning electron microscopy.
Core facilitates research, collaboration, education and outreach in all science from soft biological matter to hard physical matter, specializing in surface analysis and nano-scale characterization. Instruments include Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS), X-ray Photoelectron Spectroscopy (XPS), Fourier Transform Infrared Spectroscopy (FT-IR), Confocal Raman System, High Resolution Stylus Profilometer, 3D Optical Microscope, Spectroscopic Ellipsometer, and Zetasizer.Staff provides hand-on training, collaboration and assistance.
Mass spectrometry core lab performing proteomics, small molecule, and lipidomic analyses. Provides access to advanced analytical equipment for quantitation and structural analysis. Offers assistance in sample preparation, method development, acquisition, and data analysis.
Core supports research requiring flow cytometry techniques in basic and translational research. Provides access to equipment, and technical and scientific expertise for comprehensive analysis of immune responses. Uses standardized and optimized SOPs and study protocols to obtain reproducible and quality results for our collaborating investigators in cost-effective manner.
Software R package to run genome-wide association study (GWAS) and genome-wide by environment interaction study (GWEIS) scans using genetic data stored in binary dosage file.
Software Python toolbox for fitting Hierarchical Sequential Sampling Models using Bayesian methods.
Core provides access to technologies and services enabling study of human immune-mediated diseases. Offers expertise in human immunology along with innovative assays and technology. Core specializes in high-parameter single-cell assays utilizing conventional, spectral, and mass cytometry (CyTOF), which can be paired with genomic and bioninformatic analyses through our connections with other outstanding BRI cores. Other services include cell sorting, short-term in vitro assays, DNA/RNA extraction, qPCR, and ELISA or multiplex protein analysis (Luminex), guidance on study design and training on new technologies, execution, data analysis and interpretation.