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Software that identifies protein binding sites from ChIP-seq and nucleosome positioning experiments.
Core facilitates use of CRISPR/Cas9 genome editing technology to generate novel mouse genetic tools.
Software tools and databases for plant genomics.
Provides infrastructure for imaging based small animal research.Includes noninvasive anatomy, physiology, and biochemistry assessment for disease detection and therapeutic monitoring.
A de novo transcriptome assembler basing on the SOAPdenovo framework, adapt to alternative splicing and different expression level among transcripts., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.
Provides expertise in medicinal chemistry, metal chelate chemistry, polymer synthesis, nanoparticle production and surface functionalization, and site-specific antibody labeling. Our chemists provide custom, problem specific support for researchers in medical, chemical, and materials science fields. Specific services include consultation and assistance with the design of chemical/medicinal compounds, in house synthesis of chemical/medicinal compounds, custom nanoparticle design and synthesis, custom nanoparticle surface functionalization, polymer and dendrimer synthesis, and site specific antibody labeling.
This Gateway is a collaboration between the Consortium for Functional Glycomics (CFG) and Nature Publishing Group (NPG), providing a comprehensive resource for functional glycomics research. Use this site to stay up-to-date on glycomics news, request CFG resources, and search databases of glycan-binding proteins, glycan structures, and glycosyltransferases. The Functional Glycomics Update provides a one-stop overview of the latest research in glycobiology for specialists and non-specialists alike. It is updated monthly to bring you the latest news and selected highlights from Nature journals. In addition, it will provide two featured articles a month on the most relevant advances in the field published in NPG and other top journals. By collating new articles into a key worded research library, we hope to provide a continuously updated and broad overview of the field. Sponsor. The CFG is a large international research initiative funded by NIGMS to elucidate the roles of carbohydrate-protein interactions in cell communication at the cell surface.
Core offers immunoassay, metabolite, and HPLC services to basic, translational, and clinical investigators performing diabetes and related metabolic disease research.RIA /Biomarkers Core is located on the 12th floor of Smilow Center for Translational Research.Approximately 100 different diabetes, obesity and metabolism-related biomarkers from multiple species including human can be assayed using radioimmunoassay (RIA), enzyme-linked immunosorbent assay (ELISA, both absorbance and fluorometric), multiplex ELISA on the Luminex platform, and enzymatic and HPLC methods for an expanding variety of diabetes and metabolism related metabolites, hormones, catecholamines and cytokines derived from blood, urine, and tissue samples.
DroSpeGe provides a preview of newly sequenced Drosophila genomes, with genome maps and BLAST sequence search. Genome maps include D. melanogaster genome homology, homologies to nine eukaryote proteomes, marker gene locations, and Drosophila microsatellites. Current genome assemblies can be BLASTed, with links to genome maps of your BLAST matches. Annotation data are available in Gene Finding Format (GFF) for these whole genome comparisons.
Core provides investigators with customizable tools and methodolgies to assess in vivo exercise performance, metabolism and respiratory function, as well as in vivo and ex vivo muscle contractility. Provides guidance and training to investigators who want to learn how to collect and process muscle samples for specific uses.
Jambalaya is a plug-in created for Protg which uses Shrimp to visualize the knowledge bases the user has created. Protg is an ontology editor and a knowledge-base editor which allows domain experts to build knowledge-based systems by creating and modifying reusable ontologies and problem-solving methods.
Provides LDI affiliated investigators access to high quality, skilled data analysts. HEDAP recruits, trains, and manages group of masters level and PhD level statistical analysts. These analysts work with multi disciplinary investigators across funded projects using statistical software packages such as SAS, Stata, and R to manipulate and analyze health care data under guidance of investigators and other collaborators.
PhenoGO is a computed database designed for high throughput mining that provides phenotypic and experimental context - such as the cell type, disease, tissue, and organ - to existing annotations between gene products and Gene Ontology (GO) terms, as specified in the Gene Ontology Annotations (GOA) for multiple model organisms. Phenotypic and Experimental (P&E) contexts to identifiers are computationally mapped to general biological ontologies, including: the Cell Ontology (CO), phenotypes from the Unified Medical Language System (UMLS), species from Taxonomy of the National Center for Biotechnology Information (NCBI) taxonomy, and specialized ontologies such as Mammalian Phenotype Ontology (MP) and Mouse Anatomy (MA).
Software platform and infrastructure that aggregates, integrates, and analyzes human genetic and genomic data to spark insights into complex diseases. Data and software platform for storing, processing, and presenting genetic and genomic data.
A brain bank which provides brain tissue for interdisciplinary research in neurochemical, anatomical, epidemiological and clinical aspects of Alzheimer's disease. It provides brain tissue from Alzheimer's patients and healthy elderly brain donors to investigators who are helping further the understanding of Alzheimer's disease through research. It also gives family members of Alzheimer's patients the opportunity to obtain a confirmed diagnosis through brain autopsy. Through this program, families of individuals with either a clinical diagnosis, or those with suspected Alzheimer's disease, grant permission for a brain autopsy to be performed immediately after death.
Software package includes new cell reference for adult peripheral blood deconvolution arrayed using Illumina HumanMethylationEPIC.Optimized library for reference based deconvolution of whole blood biospecimens assayed using Illumina HumanMethylationEPIC BeadArray.
A web-based hosting service for software development projects that use the Git revision control system offering powerful collaboration, code review, and code management. It offers both paid plans for private repositories, and free accounts for open source projects. Large or small, every repository comes with the same powerful tools. These tools are open to the community for public projects and secure for private projects. Features include: * Integrated issue tracking * Collaborative code review * Easily manage teams within organizations * Text entry with understated power * A growing list of programming languages and data formats * On the desktop and in your pocket - Android app and mobile web views let you keep track of your projects on the go.
Provides programmatic access to query and download AIRR-seq data. ADC API uses JSON as its communication format, and standard HTTP methods like GET and POST. ADC API is read only and mechanism of inclusion of AIRR-seq studies into data repository is left up to repository. ADC API Specification explains how to construct and execute API requests and interpret API responses.
Database to catalog experimentally determined interactions between proteins combining information from a variety of sources to create a single, consistent set of protein-protein interactions that can be downloaded in a variety of formats. The data were curated, both, manually and also automatically using computational approaches that utilize the the knowledge about the protein-protein interaction networks extracted from the most reliable, core subset of the DIP data. Because the reliability of experimental evidence varies widely, methods of quality assessment have been developed and utilized to identify the most reliable subset of the interactions. This CORE set can be used as a reference when evaluating the reliability of high-throughput protein-protein interaction data sets, for development of prediction methods, as well as in the studies of the properties of protein interaction networks. Tools are available to analyze, visualize and integrate user's own experimental data with the information about protein-protein interactions available in the DIP database. The DIP database lists protein pairs that are known to interact with each other. By interact they mean that two amino acid chains were experimentally identified to bind to each other. The database lists such pairs to aid those studying a particular protein-protein interaction but also those investigating entire regulatory and signaling pathways as well as those studying the organization and complexity of the protein interaction network at the cellular level. Registration is required to gain access to most of the DIP features. Registration is free to the members of the academic community. Trial accounts for the commercial users are also available.
Provides expertise in anatomic pathology technologies. Offers routine and special staining, immunohistochemistry, in situ hybridization and digital pathology in support of internal and external investigators who rely on histological analysis.