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Provides small animal imaging services. Facility provides multi-modality imaging, advanced data analysis, image fusion resources, custom chemistry, and satellite animal facility for longitudinal studies.
Core provides expertise in the design and implementation of preclinical trials to test new drugs, drug combinations and novel therapeutic modalities in mouse models of human diseases.
Software reference-free intraspecies sample anomalies detetion tool based on k-mer counting.
Software interface for interacting with brain atlases. Python client to brain atlas framework that integrates brain parcellations and reference spaces at different spatial scales, and connects them with broad range of multimodal regional data features. It aims to facilitate programmatic and reproducible incorporation of brain parcellations and brain region features from different sources into neuroscience workflows.
Integrated Cell Browser features integrated single-cell RNA sequencing (scRNA-seq) and single cell ATAC-seq data from human donor-specific pancreatic islet cells. The browser enables detailed interrogation of single cell RNA-seq and single cell ATAC-seq data through intuitive visualizations. Within the single-cell browser, users can first identify and filter single-cell datasets and dataset collections. Users can visualize interactive plots of cell type clusters, gene expression, cell type abundance, and marker gene expression. Donors and their data were provided by external programs described here.
Knowledge Graph developed for the study of the human pancreas. By leveraging large language models (LLMs) and diverse data types, PanKgraph enables users to uncover biological connections and insights into diabetes pathogenesis. Previously disjointed entities such as genes, single nucleotide polymorphisms (SNPs), and pancreatic expression quantitative trait loci (eQTLs) can now be explored and connected in innovative ways.
Centralized knowledge base of the human pancreas for diabetes research. Integrates diverse type 1 diabetes (T1D) datasets with expert-curated knowledge in centralized, open-source data hub. Since users will ultimately be able to contribute their own data, this will be repository for reproducible, collaborative research within the pancreas and T1D realms.
Resource that integrates biomedical terms and biomedical relationships. This collection is curated from PubMed abstracts and biomedical repositories, offering unparalleled wealth of knowledge for researchers and practitioners in the field. The database is coupled with RESTful APIs and user-friendly web interface.
Database that uses knowledge graph to consolidate genomic datasets and annotations. Graph database for researchers to explore and investigate human genome, epigenome, transcriptome, and 4D nucleome. Genomic entities and relationships are represented as diverse nodes and edges with properties.
Core provides services in Assay Development, Assays Experimental Design, Immune Monitoring, Cytokine Assays, ELISA, multiplex Flow based and Luminex based Bead Arrays, Project Based Flow Cytometry and Data Analysis.
Software tool as framework for knowledge graph construction and the current 4 KGs. Used to extract and integrate diverse knowledge about microbes from variety of structured and unstructured sources.
Platform for health data sharing and analytics that emphasizes patient privacy and security, provides transparent and speedy access, and simplifies data discovery and analysis. Houses datasets for applied AI learning and research. Repository of freely-available medical research data, managed by the University of Toronto Temerty Centre for AI Research and Education in Medicine.
Software package as set of tools, primarily shell scripts, for processing multi-modal, high-quality MRI images for the Human Connectome Project. Minimal preprocessing pipelines for structural, functional, and diffusion MRI that were developed by the HCP to accomplish many low level tasks, including spatial artifact/distortion removal, surface generation, cross-modal registration, and alignment to standard space.
Web application tool as interactive website for SEER cancer statistics.
Core is multi-user facility located on the 4th floor in the Translational Research Building (TRB) at A4-110. It houses microscopes and image data analysis computers to provide imaging for wide range of samples, including cell structures in tissue sections, and subcellular structures and 3D morphologies of single cells. A full-time technician provides training, consultation, and guidance to researchers, from sample preparation to data analysis.
Automated rodent behavioral scoring system, complete with 3D design files and code/software. System monitors behavioral engagement using open-source software. 3D design files and necessary software has been made available, as well as code that can be used for data analysis.
Collection of databases, domain theories, and data generators that are used by machine learning community for empirical analysis of machine learning algorithms. Datasets approved to be in the repository will be assigned Digital Object Identifier (DOI) if they do not already possess one. Datasets will be licensed under a Creative Commons Attribution 4.0 International license (CC BY 4.0) which allows for the sharing and adaptation of the datasets for any purpose, provided that the appropriate credit is given
Software R package for analyzing sparse chromatin-accessibility data by estimating gain or loss of accessibility within peaks sharing the same motif or annotation while controlling for technical biases. Enables accurate clustering of scATAC-seq profiles and characterization of known and de novo sequence motifs associated with variation in chromatin accessibility. Used for analysis of sparse chromatin accessibility data from single cell or bulk ATAC or DNAse-seq data.
Web tool for pan-cancer survival analysis and visualization by using results from single sample gene set enrichment analysis. Used for pathway enrichment score-based survival analysis in cancer.Users can quickly explore impact of target pathway on survival outcomes in different tumors, assisting clinicians and researchers in further investigating mechanism of tumor development and improving clinical decision-making.
Software tool as entropy-based metric for assessing purity of single cell populations. Used to accurately quantify purity of identified cell clusters.