Both in developing and developed countries, farmers often do not protect themselves adequately, especially when applying agrochemicals that are dangerous for their health. The issue is relevant because insufficient protection is between the causes leading to intoxication of farmers and workers who handle these products. The literature suggests that both lack of training and information and low income may explain why, especially in developing countries, protective equipment is under-used. Using data from the Mekong Delta, this study addresses the issue of whether income and household wealth may help explaining the use of incomplete protections against pesticides. The results suggest that income, more than wealth, is a reason why Vietnamese farmers operating in the Mekong Delta fail in using adequate protections. In particular, the data suggest that they may prefer to divert resources to increasing the production of their fields or to buying goods that may be used both as protection and as everyday garments. This behaviour leads to underinvestment in some important protective goods. Possible public interventions to mitigate the problem are suggested; in particular, the promotion of integrated pest management techniques could be useful.

The widespread use of herbicides has increased concern about the hazards and risks to animals living in terrestrial and aquatic ecosystems. A comprehensive understanding of their effective action at different levels of biological organization is critical for establishing guidelines to protect ecosystems and human health. Dinitroanilines are broad-spectrum pre-emergence herbicides currently used for weed control in the conventional agriculture. They are considered extremely safe agrochemicals because they act specifically on tubulin proteins and inhibit shoot and root growth of plants. However, there is a lack of toxicity information regarding the potential risk of exposure to non-target organisms. The aim of the present review is to focus on side effects of the most commonly used active ingredients, e.g. pendimethalin, oryzalin, trifluralin and benfluralin, on animal non-target cells of invertebrates and vertebrates. Acute toxicity varies from slightly to high in terrestrial and aquatic species (i.e. nematodes, earthworms, snails, insects, crustaceans, fish and mammals) depending on the species-specific ability of tested organisms to adsorb and discharge toxicants. Cytotoxicity, genotoxicity and activation of oxidative stress pathways as well as alterations of physiological, metabolic, morphological, developmental and behavioural traits, reviewed here, indicate that exposure to sublethal concentrations of active ingredients poses a clear hazard to animals and humans. Further research is required to evaluate the molecular mechanisms of action of these herbicides in the animal cell and on biological functions at multiple levels, from organisms to communities, including the effects of commercial formulations.

Agriculture has been and still is one of the most influential primary operations in economic history worldwide. Its social, cultural, and political impact allows the progression and survival of humanity. Sustaining the supply of primary resources is crucial for the future. Therefore, the development of new technologies applied to agrochemicals is growing to obtain better food quality faster. Recently, nanotechnology has gained strength in this field in the last decade, mainly because of the presumed benefits that will carry with it compared with the current commercial presentations, like the decrease of risk in non-target organisms. The harm of pesticides is commonly associated with unwanted effects on human health, some with long-term genotoxic effects. Therefore, it would be relevant to set the existence of a risk or a benefit of the nanopesticides from a genotoxic point of view, comparing against those without this technology. Although some studies are concerned with its genotoxicity in live aquatic organisms, few focus on human in vitro models. Several studies conclude that some of them can induce oxidative stress, leading to DNA damage or cell death. However, there is still much to investigate to establish an accurate and complete assessment. In this review, we aim to give an overview of the genotoxic effect caused by nanopesticides in animal cells and a guide to the evolution of this topic, offering a base and critical review to facilitate future research.