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This service exclusively searches for literature that cites resources. Please be aware that the total number of searchable documents is limited to those containing RRIDs and does not include all open-access literature.

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On page 1 showing 1 ~ 3 papers out of 3 papers

Differential contribution of POMC and AgRP neurons to the regulation of regional autonomic nerve activity by leptin.

  • Balyssa B Bell‎ et al.
  • Molecular metabolism‎
  • 2018‎

The autonomic nervous system is critically involved in mediating the control by leptin of many physiological processes. Here, we examined the role of the leptin receptor (LepR) in proopiomelanocortin (POMC) and agouti-related peptide (AgRP) neurons in mediating the effects of leptin on regional sympathetic and parasympathetic nerve activity.


Neuroanatomical organization and functional roles of PVN MC4R pathways in physiological and behavioral regulations.

  • Uday Singh‎ et al.
  • Molecular metabolism‎
  • 2022‎

The paraventricular nucleus of hypothalamus (PVN), an integrative center in the brain, orchestrates a wide range of physiological and behavioral responses. While the PVN melanocortin 4 receptor (MC4R) signaling (PVNMC4R+) is involved in feeding regulation, the neuroanatomical organization of PVNMC4R+ connectivity and its role in other physiological regulations are incompletely understood. Here we aimed to better characterize the input-output organization of PVNMC4R+ neurons and test their physiological functions beyond feeding.


Elucidating the role of Rgs2 expression in the PVN for metabolic homeostasis in mice.

  • Yue Deng‎ et al.
  • Molecular metabolism‎
  • 2022‎

RGS2 is a GTPase activating protein that modulates GPCR-Gα signaling and mice lacking RGS2 globally exhibit metabolic alterations. While RGS2 is known to be broadly expressed throughout the body including the brain, the relative contribution of brain RGS2 to metabolic homeostasis remains unknown. The purpose of this study was to characterize RGS2 expression in the paraventricular nucleus of hypothalamus (PVN) and test its role in metabolic homeostasis.


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