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Label Description ILX Version Created CID Modified Time CID Type Created Time Status Creator Last modified
PHluorins PH sensitive mutations of GFP ILX:0108823 3 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Phobic Disorder Anxiety disorders in which the essential feature is persistent and irrational fear of a specific object, activity, or situation that the individual feels compelled to avoid. The individual recognizes the fear as excessive or unreasonable (MeSH). ILX:0108824 3 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Phoenetics Branch of linguistics that comprises the study of the sounds of human speech. It is concerned with the physical properties of speech sounds (phones), and the processes of their physiological production, auditory reception, and neurophysiological perception. - definition adapted from Wikipedia ILX:0108825 3 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Phonological discrimination Subjects view or listen to phonemes, syllables, or words and discriminate according to some feature of their sounds (rhyming, number of syllables, homophones, etc.). ILX:0108826 4 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Phosphatidylserine Phosphatidylserine (PS) is a phospholipid nutrient found in fish, green leafy vegetables, soybeans and rice, and is essential for the normal functioning of neuronal cell membranes and activates Protein kinase C (PKC) which has been shown to be involved in memory function. In apoptosis, phosphatidylserine is transferred to the outer leaflet of the plasma membrane. This is part of the process by which the cell is targeted for phagocytosis. PS has been shown to slow cognitive decline in animal models. PS has been investigated in a small number of double-blind placebo trials and has been shown to increase memory performance in the elderly. Because of the potentail cognitive benefits of phosphatidylserine, the substance is sold as a dietary supplement to people who believe they can benefit from an increased intake.The dietary supplement was originally processed from bovine sources however Prion disease scares in the 1990s outlawed this process, and a soy-based alternative was adopted. Pharmacology: Phosphatidylserine is indicated in the treatment of cognitive impairment, including Alzheimer's disease, age-associated memory impairment and some non-Alzheimer's dementias. Further research is required before phosphatidylserine can be indicated for immune enhancement or for reduction of exercise stress. Phosphatidylserine was first isolated from brain lipids called cephalins. The major cephalins are phosphatidylserine and phophatidylethanolamine. Phosphatidylserine is involved in signal transduction activity as well as being a basic structural component of biologic membranes. Mechanism of action: Cholinergic hypofunction is thought to account in part for the cognitive deficits found in Alzheimer's disease. The most commonly used drugs for the treatment of Alzheimer's disease are reversible acetylcholinesterase inhibitors. The rationale of these drugs is to increase acetylcholine levels in the brains of Alzheimer's patients, and they may be somewhat effective in some cases. Phosphatidylserine restores acetylcholine release in aging humans by maintaining an adequate supply of the molecule and is able to increase the availability of endogenous choline for de novo acetylcholine synthesis. The hippocampus of the brain is believed to be important for cognitive processes and is affected in those with Alzheimer's disease. The dendritic spines of pyramidal cells, the post-synaptic target of the excitatory input to the hippocampus, have been proposed as a substrate for information storage. Age-dependent dendritic spine loss in pyramidal neurons has been reported in the human brain, and the extent of synaptic loss appears to correlate with the degree of cognitive impairment. Phosphatidylserine treatment prevents the age-related reduction in dendritic spine density in rat hippocampus. Protein kinase C facilitation of acetylcholine release has been reported in rats. Phosphatidylserine was found to restore protein kinase C activity in aging rats. Stimulation of calcium uptake by brain synaptosomes and activation of protein kinase C are yet other speculative mechanisms of phosphatidylserine's putative cognition-enhancing action. Drug type: Approved. Nutraceutical. Small Molecule. Drug category: Dietary supplement. Micronutrient ILX:0108827 4 FDI Lab - SciCrunch.org 08/24/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex troy sincomb
Phospholipid ILX:0108828 3 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Phosphorescence A fluorescence in which the emittence continues after absorption has ceased. ILX:0108829 3 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Phosphorus, white Inorganic Compound;Non-Metal; White phosphorus is an allotrope of elemental phosphorus. It does not occur naturally, but is manufactured from phosphate rocks. Since it is a smoke-producing and incendiary agent, it has many military applications, especially in smokescreens, bombs, artillery, and mortars. It is also used by industry to produce phosphoric acid and other chemicals for use in fertilizers, food additives, and cleaning compounds. ILX:0108830 3 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Phosphorylated Molecular Quality Indicates a phosphate (PO4) added to protein molecule or small molecule. ILX:0108831 4 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Photo sensation ILX:0108832 3 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Photoactivated localization microscopy A light microscopic imaging assay that builds up an image from many dark fluorophores that can be photoactivated into a fluorescing state by a flash of light. Because photoactivation is stochastic, only a few, well separated molecules "turn on." Then Gaussians are fit to their PSFs to high precision. After the few bright dots photobleach, another flash of the photoactivating light activates random fluorophores again and the PSFs are fit of these different well spaced objects. This process is repeated many times, building up an image molecule-by-molecule; and because the molecules were localized at different times, the "resolution" of the final image can be much higher than that limited by diffraction. (Adapted from Wikipedia) ILX:0108833 4 FDI Lab - SciCrunch.org 08/24/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex troy sincomb
Photograph A photograph is created by projecting an image onto a photosensitive surface such as a chemically treated plate or film, CCD receptor, etc. ILX:0108834 3 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Photoinsensitive A photosensitivity quality inhering in a bearer by virtue of its lacking photosensitivity. ILX:0108835 3 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Photometric Interpretation Specifies the intended interpretation of the pixel data. ILX:0108836 4 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Photoreceptor cell (FBbt Term) ILX:0108837 3 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Photoreceptor cell of Bolwig organ Photoreceptor cell that is part of a Bolwig's organ. Unlike the photoreceptors of the adult eye, eyelet and ocellus, these photoreceptors do not contain rhabdomeres, but instead have apical surfaces which are folded into numerous microtubule containing lamellae. ILX:0108838 4 FDI Lab - SciCrunch.org 08/24/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex troy sincomb
Photoreceptor role Functional role of nerve cell that functions to transduce light energy into a neural signal ILX:0108839 3 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Photosensitive A photosensitivity quality inhering in a bearer by virtue of its exhibiting photosensitivity. ILX:0108840 3 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Photosensitivity A quality inhering to the bearer by virtue of its sensitivity to the action of radiant energy. ILX:0108841 3 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Phototimer Setting Nominal percentage phototimer setting, where a more positive value indicates greater exposure and a more negative value indicates less exposure. ILX:0108842 4 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex

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