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Label Description ILX Version Created CID Modified Time CID Type Created Time Status Creator Last modified
Nerve tract White matter structure of CNS that contains axons that arise predominantly in one central nervous system part and terminate in another. Tracts are generally named by their region or origin followed by their region of primary termination, e.g., mammillothalamic tract contains axons that arise from neurons in the mammillary bodies and terminate in the thalamus. ILX:0107421 11 FDI Lab - SciCrunch.org 06/23/2020 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Nervous system The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body.In all animals the nervous system probably differentiates from the embryonic ectodermal layer (Swanson, 2014).The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior."The term was introduced by Monro in 1873. ILX:0107422 11 FDI Lab - SciCrunch.org 06/23/2020 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex troy sincomb
Nervous system cell A cell comprising the nervous tissue of the nervous system, mostly of neuroectodermal origin. ILX:0107423 4 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Nervous system disease Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle (MeSH). ILX:0107424 3 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Nervous system function An activity or purpose natural to or intended for part of or a whole nervous system. ILX:0107425 3 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Nervous system neoplastic disease Abnormal mass of tissue in the nervous system. ILX:0107426 3 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Nervous System Paraneoplastic Syndrome Degenerative or inflammatory conditions affecting the central or peripheral nervous system that develop in association with a systemic neoplasm without direct invasion by tumor. They may be associated with circulating antibodies that react with the affected neural tissue (MeSH). ILX:0107427 3 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Nervous System Trauma Traumatic injuries to the brain, cranial nerves, spinal cord, autonomic nervous system, or neuromuscular system, including iatrogenic injuries induced by surgical procedures (MeSH). ILX:0107428 3 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Nesfatin 1 An 82 amino acid peptide that suppresses food intake after intracerebroventricular injection (MeSH) ILX:0107429 3 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Netherlands Bioinformatics Centre A collaborative institute of the bioinformatics groups in the Netherlands that perform cutting-edge research, develop novel tools and support platforms, create an e-science infrastructure and educate the next generations of bioinformaticians. They aim to build and maintain a strong bioinformatics and e-bioscience community that meets the (growing) demand for bioinformatics expertise, infrastructure and personnel in the Dutch life sciences field and provides a stimulating force for advanced research in biology.The NBIC grants aim to support the NBIC projects and (the visibility of) the NBIC community. Therefore, only people working in NBIC partner organizations can apply for sponsoring by NBIC. Positions for postdocs and others are available and there is a yearly conference. ILX:0107430 5 FDI Lab - SciCrunch.org 12/09/2019 FDI Lab - SciCrunch.org term 12/09/2016 -2 NeuroLex NeuroLex
Netherlands Genomics Initiative ILX:0107431 4 FDI Lab - SciCrunch.org 12/09/2019 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Netilmicin Semisynthetic 1-N-ethyl derivative of sisomycin, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity. (PubChem) Pharmacology: Netilmicin is a semisynthetic, water soluble antibiotic of the aminoglycoside group, produced by the fermentation of Micromonospora inyoensis, a species of actinomycete. Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. It is active at low concentrations against a wide variety of pathogenic bacteria including Escherichia coli, bacteria of the Klebsiella-Enterobacter-Serratia group, Citrobacter sp., Proteus sp. (indole-positive and indole-negative), including Proteus mirabilis, P. morganii, P. rettgrei, P. vulgaris, Pseudomonas aeruginosa and Neisseria gonorrhoea. Netilmicin is also active in vitro against isolates of Hemophilus influenzae, Salmonella sp., Shigella sp. and against penicillinase and non-penicillinase-producing Staphylococcus including methicillin-resistant strains. Some strains of Providencia sp., Acinetobacter sp. and Aeromonas sp. are also sensitive to netilmicin. Many strains of the above organisms which are found to be resistant to other aminoglycosides, such as kanamycin, gentamicin, tobramycin and sisomicin, are susceptible to netilmicin in vitro. Occasionally, strains have been identified which are resistant to amikacin but susceptible to netilmicin. The combination of netilmicin and penicillin G has a synergistic bactericidal effect against most strains of Streptococcus faecalis (enterococcus). The combined effect of netilmicin and carbenicillin or ticarcillin is synergistic for many strains of Pseudomonas aeruginosa. In addition, many isolates of Serratia, which are resistant to multiple antibiotics, are inhibited by synergistic combinations of netilmicin with carbenicillin, azlocillin, mezlocillin, cefamandole, cefotaxime or moxalactam. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses. Mechanism of action: Aminoglycosides like netilmicin "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically netilmicin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes, leaving the bacterium unable to synthesize proteins vital to its growth. Drug type: Approved. Small Molecule. Drug category: Aminoglycosides. Anti-Bacterial Agents. Protein Synthesis Inhibitors ILX:0107432 4 FDI Lab - SciCrunch.org 08/24/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex troy sincomb
Netted Covered with reticulated lines of a different hue or degree of saturation. ILX:0107433 3 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Network analysis software ILX:0107434 3 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Network graph visualization software ILX:0107435 3 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Network interaction model ILX:0107436 3 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Networks of Centres of Excellence of Canada The Networks of Centres of Excellence (NCE) fosters multi-disciplinary, multi-sectoral partnerships between academia, industry, government and not-for-profit organizations. It supports academic research, the commercialization of products and ideas, and the development of significant Canadian business advantages. The partnerships that this initiative cultivates result in ideas that are transformed into economic and social benefits for all Canadians. ILX:0107437 3 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
NeurabinI PDZ containing proteins with F-actin binding protein activity. ILX:0107438 4 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Neural Cell Adhesion Molecule Cell adhesion molecule involved in a diverse range of contact-mediated interactions among neurons, astrocytes, oligodendrocytes, and myotubes. It is widely but transiently expressed in many tissues early in embryogenesis. Four main isoforms exist, including CD56; (ANTIGENS, CD56); but there are many other variants resulting from alternative splicing and post-translational modifications. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, pp115-119) (MSH) ILX:0107439 4 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex
Neural circuit neural network describes a population of physically interconnected neurons or a group of disparate neurons whose inputs or signalling targets define a recognizable circuit. Communication between neurons often involves an electrochemical process. The interface through which they interact with surrounding neurons usually consists of several dendrites (input connections), which are connected via synapses to other neurons, and one axon (output connection). If the sum of the input signals surpasses a certain threshold, the neuron sends an action potential (AP) at the axon hillock and transmits this electrical signal along the axon.In contrast, a neuronal circuit is a functional entity of interconnected neurons that influence each other (similar to a control loop in cybernetics). - definition adapted from Wikipedia ILX:0107440 3 FDI Lab - SciCrunch.org 06/18/2018 FDI Lab - SciCrunch.org term 12/09/2016 0 NeuroLex NeuroLex

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