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Integrated Models is a virtual database currently indexing computational models from: CellML, ModelDB, Open Source Brain, SimTK.
(last updated: Nov 23, 2022)
Data or Model Models| Database | Model Name | Simulator Software | Model Type | Neurons | Neurotransmitters | Receptors | ||||
|---|---|---|---|---|---|---|---|---|---|---|
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ModelDB | Pyramidal Neuron: Deep, Thalamic Relay and Reticular, Interneuron (Destexhe et al 1998, 2001) | NEURON | Neuron or other electrically excitable cell | Thalamus geniculate nucleus/lateral principal GLU cell, Thalamus reticular nucleus GABA cell, Neocortex L5/6 pyramidal GLU cell | GabaA, GabaB, AMPA, Gaba | I Sodium, I Calcium, I Potassium, I Na,t, I T low threshold, I K, I M | Activity Patterns, Bursting, Action Potentials, Calcium dynamics | This package shows single-compartment models of different classes of cortical neurons, such as the "regular-spiking", "fast-spiking" and "bursting" (LTS) neurons. The mechanisms included are the Na+ and K+ currents for generating action potentials (INa, IKd), the T-type calcium current (ICaT), and a slow voltage-dependent K+ current (IM). See http://cns.fmed.ulaval.ca/alain_demos.html | Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr] | |
|
ModelDB | Thalamic reticular neurons: the role of Ca currents (Destexhe et al 1996) | NEURON | Neuron or other electrically excitable cell | Thalamus reticular nucleus GABA cell | I Sodium, I Calcium, I Potassium, I Na,t, I T low threshold, I K | Action Potential Initiation, Dendritic Action Potentials, Bursting, Simplified Models, Active Dendrites, Influence of Dendritic Geometry, Detailed Neuronal Models, Action Potentials, Calcium dynamics | The experiments and modeling reported in this paper show how intrinsic bursting properties of RE cells may be explained by dendritic calcium currents. | Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr] | ||
|
ModelDB | Thalamic transformation of pallidal input (Hadipour-Niktarash 2006) | MATLAB | Realistic Network, Neuron or other electrically excitable cell | Thalamus geniculate nucleus/lateral principal GLU cell, Thalamus reticular nucleus GABA cell | GabaA, GabaB, AMPA | I Potassium, I Na,t, I T low threshold, I K, I h | Parkinson's | "In Parkinson’s disease, neurons of the internal segment of the globus pallidus (GPi) display the low-frequency tremor-related oscillations. These oscillatory activities are transmitted to the thalamic relay nuclei. Computer models of the interacting thalamocortical (TC) and thalamic reticular (RE) neurons were used to explore how the TC-RE network processes the low-frequency oscillations of the GPi neurons. ..." | Hadipour-Niktarash, Arash [arash.hadipour at gmail.com] | |
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ModelDB | Thalamocortical loop with delay for investigation of absence epilepsy (Liu et al 2019) | XPP | Neuron or other electrically excitable cell | Thalamus reticular nucleus GABA cell | Gaba, Glutamate | GabaA, GabaB, AMPA | I T low threshold, I M, I h, I Sodium, I Potassium | Conductance based network model of one thalamic reticular neuron, one thalamic pyramidal neuron and one cortical pyramidal neuron. Used to show that large delay in the corticothalamic connection can lead to multistability. | Liu, Yu, Campbell, Sue Ann [sacampbell at uwaterloo.ca] |
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