Thyroid hormones (THs) are key metabolic regulators coordinating short- and long-term energy needs. In skeletal muscle, THs modulate energy metabolism in pathophysiological conditions. Indeed, hypo- and hyperthyroidism are leading causes of muscle weakness and strength; however, the metabolic pathways underlying these effects are still poorly understood. Using molecular, biochemical, and isotope-tracing approaches combined with mass spectrometry and denervation experiments, we find that THs regulate glutamine metabolism and anaplerotic fluxes by up-regulating the glutamate pyruvate transaminase 2 (GPT2) gene. In humans, GPT2 autosomal recessive mutations cause a neurological syndrome characterized by intellectual disability, microcephaly, and progressive motor symptoms. Here, we demonstrate a role of the TH/GPT2 axis in skeletal muscle in which it regulates muscle weight and fiber diameter in resting and atrophic conditions and results in protection from muscle loss during atrophy. These results describe an anabolic route by which THs rewire glutamine metabolism toward the maintenance of muscle mass.
Pubmed ID: 35196498 RIS Download
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View all literature mentionsThis monoclonal targets Thyroid Hormone Receptor antibody [C3]
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View all literature mentionsThis polyclonal secondary targets IgM (Heavy chain)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets Myosin Heavy Chain Type IIB
View all literature mentionsThis monoclonal targets Myosin Heavy Chain Type IIA
View all literature mentionsThis monoclonal targets Myosin (Skeletal, Fast)
View all literature mentionsThis monoclonal targets Myosin (Skeletal Slow) antibody produced in mouse
View all literature mentionsThis polyclonal targets Phospho-p70 S6 Kinase (Thr389)
View all literature mentionsThis polyclonal targets p70 S6 Kinase
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View all literature mentionsThis polyclonal targets H,M,R,Mk,Ch,Rb,Sh,Xenopus
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsCell line C2C12 is a Spontaneously immortalized cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsThis polyclonal targets H,M,R,Mk,Ch,Rb,Sh,Xenopus
View all literature mentionsMus musculus with name C57BL/6N-Gpt2tm1a(KOMP)Wtsi/MbpMmucd from MMRRC.
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