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Fear renewal activates cyclic adenosine monophosphate signaling in the dentate gyrus.

Brain and behavior | 2019

Fear renewal, the context-specific relapse of a conditioned fear after extinction, is a widely pursued model of post-traumatic stress disorder and phobias. However, its cellular and molecular mechanisms remain poorly understood. The dentate gyrus (DG) has emerged as a critical locus of plasticity with relevance to memory, anxiety disorders, and depression, and it contributes to fear memory retrieval. Here, we have identified the role of the DG in fear renewal and its molecular mechanism.

Pubmed ID: 31313894 RIS Download

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COMPASS (tool)

RRID:SCR_015874

Algorithm for MATLAB and the EEGLAB toolbox that enables the automatic detection of independent components from an ICA that represent event-related brain potentials. It performs automatic Independent Component (IC) selection with respect to the contributions of the ICs to a certain ERP.

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SD (tool)

RRID:RGD_70508

Rattus norvegicus with name SD from RGD.

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