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Publication

Ursodeoxycholic acid inhibits platelet activation and thrombosis via TREM2: Evidence from mouse models and human studies.

Xiaowen Wu | Yulong Zhang | Qingyuan Yang | Liwen Xue | Yifan Guo | Li Li | Changran Liu | Meina Jin | Guanxing Pan | Jianlong Men | Xiongwen Chen | Jianzeng Dong | Bing Chen | Zhongren Ding
British journal of pharmacology | 2026

Current antiplatelet therapies effectively prevent thrombosis but are associated with an increased risk of bleeding, highlighting the need for safer alternatives. Ursodeoxycholic acid (UDCA) is a bile acid derivative with an established clinical safety profile, but its effects on platelet function and thrombosis remain poorly defined.

Pubmed ID: 42386516

Research resources used in this publication

None found

Additional research tools detected in this publication

None found

Antibodies used in this publication

Associated grants

  • Agency: National Natural Science Foundation of China,
    Id: 82173818
  • Agency: Tianjin Medical University,

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.

Goat anti-mouse IgG (H+L), HRP conjugate (antibody)

RRID:AB_2722565

This polyclonal targets IgG (H+L)

View all literature mentions

TREM2 Antibody (antibody)

RRID:AB_3102752

This polyclonal targets nan

View all literature mentions

INPP5D antibody (antibody)

RRID:AB_10667407

This polyclonal targets INPP5D

View all literature mentions

Goat anti-rabbit IgG (H+L), HRP conjugate (antibody)

RRID:AB_2722564

This unknown targets IgG

View all literature mentions

GAPDH Rabbit mAb (antibody)

RRID:AB_2862549

This monoclonal targets

View all literature mentions

Phospho-Akt (Ser473) (D9E) XP® Rabbit mAb (antibody)

RRID:AB_2315049

This monoclonal targets Phospho-Akt (Ser473)

View all literature mentions

Phospho-SHIP1 (Tyr1020) Antibody (antibody)

RRID:AB_2296062

This polyclonal targets INPP5D

View all literature mentions

About

The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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Department of Neurosciences, School of Medicine

University of California, San Diego

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