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Construction of a diagnostic model for colorectal cancer based on exosome-related genes: integration of immune cell differentials and molecular docking.

Yulai Yin | Li Li | Shuang Liu | Yixuan Xie | Yuwei Li | Yuan Gao | Chen Xu | Yan Wang
Translational cancer research | 2026

Colorectal cancer (CRC) is one of the most common malignancies of the digestive tract, with conventional clinical diagnoses often made at advanced stages. There is an urgent need for a genetic diagnostic model to predict the onset of CRC at early stages, thereby reducing the disease burden associated with it. This study aimed to construct and validate a CRC diagnostic model based on exosome-related genes and to explore potential target drugs.

Pubmed ID: 42180950

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This is a list of tools and resources that we have found mentioned in this publication.


GeneHancer (tool)

RRID:SCR_023953

Database of human regulatory elements like enhancers and promoters, and their inferred target genes which is embedded in GeneCards, human gene compendium. Associations between regulatory elements and target genes were based on multiple sources of linking molecular data, along with distance.

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CB-dock2 (tool)

RRID:SCR_026134

Web server for protein-ligand blind docking, integrating cavity detection, docking and homologous template fitting. Given the three-dimensional structure of protein and ligand, can predict their binding sites and affinity for computer-aided drug discovery.

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