Synergistic repair of pelvic floor supportive tissues in rats with stress urinary incontinence by electroacupuncture combined with repetitive transspinal magnetic stimulation and mechanisms of action.

Stress urinary incontinence (SUI), a common condition impacting quality of life, stems frominvoluntary urine leakage due to increased abdominal pressure. Its pathology involves excessive extracellular matrix (ECM)degradation, particularly collagen, in pelvic floor tissues, driven by an imbalance between matrix metalloproteinases (MMPs)and their inhibitors (TIMPs). While electroacupuncture (EA) and repetitive Trans-spinal Magnetic Stimulation (rTSMS) areeach beneficial for SUI, their combined synergistic effects and mechanisms are unexplored. We hypothesized that combinedEA and rTSMS would synergistically repair pelvic floor support structures in SUI rats by modulating the TGF-β1/CTGFsignaling pathway and ECM metabolism.

Pubmed ID: 42126615