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Neurocognitive impairment and substance use in adult survivors of childhood cancer: a cross-sectional analysis from the Childhood Cancer Survivor Study.

Rachel Webster | Eleanor O Chambers | Weiyu Qiu | Rikeenkumar Dhaduk | Lei Wang | Yutaka Yasui | Yan Yuan | Paul C Nathan | Wendy Leisenring | Gregory T Armstrong | Rebecca Howell | Tilman Schulte | Matthew Yalch | Matthew Cordova | Kevin R Krull | Tara M Brinkman | Kim Edelstein
EClinicalMedicine | 2026

Adult survivors of childhood cancer are at risk for neurocognitive impairment, emotional distress, and chronic pain, factors independently associated with substance use. However, interrelationships among these factors and their association with substance use remain poorly understood.

Pubmed ID: 42094234

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: P30 CA021765
  • Agency: NCI NIH HHS, United States
    Id: U24 CA055727

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ClinicalTrials.gov (tool)

RRID:SCR_002309

Registry and results database of federally and privately supported clinical trials conducted in United States and around world. Provides information about purpose of trial, who may participate, locations, and phone numbers for more details. This information should be used in conjunction with advice from health care professionals.Offers information for locating federally and privately supported clinical trials for wide range of diseases and conditions. Research study in human volunteers to answer specific health questions. Interventional trials determine whether experimental treatments or new ways of using known therapies are safe and effective under controlled environments. Observational trials address health issues in large groups of people or populations in natural settings. ClinicalTrials.gov contains trials sponsored by National Institutes of Health, other federal agencies, and private industry. Studies listed in database are conducted in all 50 States and in 178 countries.

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GenomeRNAi (tool)

RRID:SCR_013088

GenomeRNAi is a database of phenotypes from systematic RNA interference (RNAi) screens in cultured Drosophila cells. The phenotype database can be searched by keywords, RNAi identifiers or Drosophila gene sequences. Searches with homologous sequences from human or C. elegans are also possible. Integrated tools evaluate the specificity of long double-stranded RNAs (RNAi probes) by similarity searches against all predicted Drosophila transcripts. This site can also be used to identify pre-designed RNAi probes from available Drosophila RNAi libraries. Caenorhabditis elegans genome, human genome

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