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Publication

ATAD3A promotes bladder cancer progression by regulating glycolysis through MYC stabilization.

Xiao Xiao | Xingshan Lu | Junxiong Peng | Li Li | Xuesong Bai | Chunlin Zhang | Zhenwei Feng | Yuhua Mei | Xinyuan Li | Hubin Yin | Xin Gou | Yunfeng He
Journal of translational medicine | 2026

Bladder cancer (BCa) remains a major global health challenge with high recurrence and progression rates. Although metabolic reprogramming is recognized as a hallmark of cancer, the molecular mechanisms driving glycolysis in BCa are incompletely understood. ATAD3A, a mitochondrial membrane protein implicated in various malignancies, has not been characterized in BCa. This study aimed to investigate the role of ATAD3A in BCa progression and elucidate the molecular mechanisms linking ATAD3A to tumor metabolism.

Pubmed ID: 42001122

Research resources used in this publication

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Associated grants

  • Agency: National Natural Science Foundation of China,
    Id: 82472779
  • Agency: National Natural Science Foundation of China,
    Id: 82303655
  • Agency: Fuling District Science and Technology Research Program,
    Id: FLKJ.2024AAN3066
  • Agency: Fuling District Science and Health Joint Fund,
    Id: NO.2024KWLH016

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

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LIMMA (tool)

RRID:SCR_010943

Software package for the analysis of gene expression microarray data, especially the use of linear models for analyzing designed experiments and the assessment of differential expression.

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Biorender (tool)

RRID:SCR_018361

Web tool for graphical illustrations for biological systems by BioRender. Used for articles and presentations. Collection of pre made icons and templates from life science fields for scientific illustrations. Customized icons possible on request.

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BALB/cAnN-Foxn1nu/nu/Rj (tool)

RRID:IMSR_RJ:BALB-C-NUDE

Mus musculus with name BALB/cAnN-Foxn1nu/nu/Rj from IMSR.

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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