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OBJECTIVE: To investigate the role of centrin-2 (CETN2) in platinum resistance and its underlying mechanisms in ovarian cancer. METHODS: We conducted a pan-cancer analysis of CETN2 expression and its associated genes using the STRING and TIMER databases. Data from the GEO and TCGA databases were employed for survival, clinical correlation, and prognostic analyses. Enrichment and co-expression analyses were performed to identify relevant pathways and genes. We also analyzed the tumor microenvironment, immune checkpoints, and drug sensitivity. For clinical validation, quantitative real-time PCR was used to measure CETN2 expression in patient samples and assess its correlation with chemotherapy response. Predictive models, including logistic regression and decision trees, were constructed. Their performance in predicting chemotherapy outcomes was evaluated using receiver operating characteristic (ROC) curves, and the prognostic impact of CETN2 was assessed via Kaplan-Meier survival analysis. RESULTS: CETN2 mRNA expression was significantly elevated in cisplatin-resistant samples. CETN2 was associated with the nucleotide excision repair (NER), oxidative phosphorylation, and cell cycle pathways and showed a negative correlation with several immune checkpoints. CETN2 expression demonstrated notable predictive value for chemotherapy response, particularly in platinum-sensitive ovarian cancer. It influenced stromal and immune-related scores in the tumor microenvironment, and differential expression levels correlated with significant variations in sensitivity to specific drugs. In clinical samples, CETN2 expression was linked to immune infiltration patterns. Protein expression of CETN2 was significantly higher in platinum-resistant patients compared to platinum-sensitive patients and showed predictive utility for chemotherapy outcomes. CONCLUSION: Upregulation of CETN2 may contribute to cisplatin resistance through pathways involving nucleotide excision repair, oxidative phosphorylation, and the cell cycle. CETN2 holds potential as a biomarker for platinum-based chemotherapy response and prognostic evaluation in ovarian cancer.
Pubmed ID: 41882782
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Software package used for interactive, or batched, statistical analysis in social science, health sciences and marketing. Software platform offers advanced statistical analysis, a library of machine-learning algorithms, text analysis, open-source extensibility, integration with big data and deployment into applications.Versions that were produced by SPSS Inc. before the IBM acquisition (Versions 18 and earlier) would be given origin or publisher of SPSS Inc. in Chicago.
View all literature mentionsSoftware package for interpreting gene expression data. Used for interpretation of a large-scale experiment by identifying pathways and processes.
View all literature mentionsDatabase of known and predicted protein interactions. The interactions include direct (physical) and indirect (functional) associations and are derived from four sources: Genomic Context, High-throughput experiments, (Conserved) Coexpression, and previous knowledge. STRING quantitatively integrates interaction data from these sources for a large number of organisms, and transfers information between these organisms where applicable. The database currently covers 5''214''234 proteins from 1133 organisms. (2013)
View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE, documented on January 19, 2022.
View all literature mentionsA unified data repository of the National Cancer Institute (NCI)'s Genomic Data Commons (GDC) that enables data sharing across cancer genomic studies in support of precision medicine. The GDC supports several cancer genome programs at the NCI Center for Cancer Genomics (CCG), including The Cancer Genome Atlas (TCGA), Therapeutically Applicable Research to Generate Effective Treatments (TARGET), and the Cancer Genome Characterization Initiative (CGCI). The GDC Data Portal provides a platform for efficiently querying and downloading high quality and complete data. The GDC also provides a GDC Data Transfer Tool and a GDC API for programmatic access.
View all literature mentionsSoftware R package for statistical analysis and visualization of functional profiles for genes and gene clusters.
View all literature mentionsWeb server for comprehensive analysis of tumor infiltrating immune cells. Web tool for systematical analysis of immune infiltrates across diverse cancer types. Allows users to input function specific parameters, with resulting figures dynamically displayed to access tumor immunological, clinical, and genomic features.
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