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Targeted muscle reinnervation attenuates neuropathic pain and neuroma development in a rat model of tibial nerve transection.

Li Li | Ainizier Yalikun | QiYue Zhang | DeBin Xiong | Tao Jiang | Fan Bu | QingTang Zhu | Aihemaitijiang Yusufu
Frontiers in bioengineering and biotechnology | 2026

Peripheral nerve injuries often lead to painful neuroma formation and chronic neuropathic pain, and the optimal surgical strategy for prevention remains debated. Targeted muscle reinnervation (TMR), regenerative peripheral nerve interfaces (RPNI), and nerve-in-muscle implantation (NIM) are surgical techniques developed to mitigate neuroma-related pain, but their relative efficacy has not been compared systematically. This preclinical study compared TMR, NIM, and two RPNI variants in a rat tibial nerve transection model to identify which approach best reduces neuroma formation and pain.

Pubmed ID: 41836766

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SD (tool)

RRID:RGD_70508

Rattus norvegicus with name SD from RGD.

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