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Lactobacillus rhamnosus MY-1 alleviates deoxynivalenol-induced oxidative stress, inflammation, and gut microbiota dysbiosis both in vivo and in vitro.

Yukai Lin | Ruibiao Wang | Jie Yao | Hanqing Zhao | Zuhua Yu | Bo Wen | Yanyan Jia | Chengshui Liao | Rongxian Guo | Lei Wang | Xiaojing Xia | Yanzhao Xu | Ke Ding
Frontiers in microbiology | 2026

Deoxynivalenol (DON), a prevalent mycotoxin in grains and feed, poses a serious threat to animal health by inducing intestinal dysfunction. While some probiotics are known to mitigate DON toxicity, the multifaceted protective effects of Lactobacillus rhamnosus MY-1-a strain with high DON-degradation capacity and a proven safety profile-require comprehensive evaluation. This study aimed to systematically assess the ability of MY-1 to alleviate DON-induced oxidative stress, inflammation, and gut microbiota dysbiosis, and to elucidate its underlying mechanisms.

Pubmed ID: 41777545

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SILVA (tool)

RRID:SCR_006423

High quality ribosomal RNA databases providing comprehensive, quality checked and regularly updated datasets of aligned small (16S/18S, SSU) and large subunit (23S/28S, LSU) ribosomal RNA (rRNA) sequences for all three domains of life (Bacteria, Archaea and Eukarya). Supplementary services include a rRNA gene aligner, online tools for probe and primer evaluation and optimized browsing, searching and downloading on the website. The extensively curated SILVA taxonomy and the new non-redundant SILVA datasets provide an ideal reference for high-throughput classification of data from next-generation sequencing approaches. Alignment tool, SINA, is available for download as well as available for use online.

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BALB/cAnNCrl (tool)

RRID:MGI:2683685

laboratory mouse with name BALB/cAnNCrl from MGI.

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