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Publication

Population-level morphological analysis of paired CO2- and odor-sensing olfactory neurons in D. melanogaster via volume electron microscopy.

Jonathan Choy | Shadi Charara | Kalyani Cauwenberghs | Quintyn McKaughan | Keun-Young Kim | Mark H Ellisman | Chih-Ying Su
eLife | 2025

Dendritic morphology is a defining characteristic of neuronal subtypes. In Drosophila, heterotypic olfactory receptor neurons (ORNs) expressing different receptors display diverse dendritic morphologies, but whether such diversity exists among homotypic ORNs remains unclear. Using serial block-face scanning electron microscopy on cryofixed tissues, we analyzed the majority of CO2-sensing neurons (ab1C) and their odor-sensing neighbors (ab1D) in the Drosophila melanogaster antenna. Surprisingly, ab1C neurons featured flattened, sheet-like dendrites-distinct from the cylindrical branches typical of odor-sensing neurons-and displayed remarkable diversity, ranging from plain sheets to tube-like structures that enclose several neighboring dendrites, forming 'dendrite-within-dendrite' structures. Similarly, ab1D dendrites varied from simple, unbranched forms to numerously branched morphologies. These findings suggest that morphological heterogeneity is common even among homotypic ORNs, potentially expanding their functional adaptability and ranges of sensory physiological properties.

Pubmed ID: 40709917

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None found

Associated grants

  • Agency: NIDCD NIH HHS, United States
    Id: R01 DC021551
  • Agency: National Institute of Allergy and Infectious Diseases,
    Id: R21AI169343
  • Agency: NIDCD NIH HHS, United States
    Id: R21DC020536
  • Agency: NIGMS NIH HHS, United States
    Id: R01GM138780
  • Agency: NINDS NIH HHS, United States
    Id: U24 NS120055
  • Agency: NIDCD NIH HHS, United States
    Id: R01DC021551
  • Agency: NIAID NIH HHS, United States
    Id: R21 AI169343
  • Agency: NINDS NIH HHS, United States
    Id: U24NS120055
  • Agency: NIDCD NIH HHS, United States
    Id: R01DC016466
  • Agency: NIDCD NIH HHS, United States
    Id: R21 DC020536
  • Agency: NIGMS NIH HHS, United States
    Id: R01 GM138780
  • Agency: NIDCD NIH HHS, United States
    Id: R01 DC016466

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IMOD (tool)

RRID:SCR_003297

A free, cross-platform set of image processing, modeling and display programs used for tomographic reconstruction and for 3D reconstruction of EM serial sections and optical sections. The package contains tools for assembling and aligning data within multiple types and sizes of image stacks, viewing 3-D data from any orientation, and modeling and display of the image files. IMOD 4.1.8 Is Now Available for Linux, Windows, and Mac OS X

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RRID:SCR_024867

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P{y[+t7.7] w[+mC]=10XUAS-myc-APEX2-Orco}attP40 (organism)

RRID:BDSC_79214

Drosophila melanogaster with name P{y[+t7.7] w[+mC]=10XUAS-myc-APEX2-Orco}attP40 from BDSC.

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w[*] TI{w[+m*]=GAL4}Or7a[KI-GAL4] (organism)

RRID:BDSC_91810

Drosophila melanogaster with name w[*] TI{w[+m*]=GAL4}Or7a[KI-GAL4] from BDSC.

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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