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Pseudomonas syringae pv. actinidiae (Psa), the causative agent of kiwifruit canker disease, poses significant threats to global kiwifruit production, resulting in substantial economic losses. Disease incidence is notably higher under cooler temperatures (<20℃), yet the molecular mechanisms underlying Psa's temperature-dependent virulence remain poorly understood. Here, we identify RS16350, encoding a heat shock protein homolog, as a positive regulator of Psa pathogenicity specifically at low temperature (16℃) but not at optimal growth temperature (28℃). Mechanistic studies reveal that RS16350 physically interacts with HrpL, the RpoN-dependent sigma factor controlling type III secretion system (T3SS) expression in Psa. This interaction enhances HrpL's binding affinity to the hrp-box promoter element, thereby upregulating T3SS effector genes and increasing virulence. We designate this novel regulator as TrpR2 (temperature-responsive pathogenic regulator 2). These findings provide molecular insights into temperature-modulated virulence in a key plant pathogen and identify potential targets for developing innovative disease control strategies.
Pubmed ID: 40487197
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NIH genetic sequence database that provides annotated collection of all publicly available DNA sequences for almost 280 000 formally described species (Jan 2014) .These sequences are obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects, including whole-genome shotgun (WGS) and environmental sampling projects. Most submissions are made using web-based BankIt or standalone Sequin programs, and GenBank staff assigns accession numbers upon data receipt. It is part of International Nucleotide Sequence Database Collaboration and daily data exchange with European Nucleotide Archive (ENA) and DNA Data Bank of Japan (DDBJ) ensures worldwide coverage. GenBank is accessible through NCBI Entrez retrieval system, which integrates data from major DNA and protein sequence databases along with taxonomy, genome, mapping, protein structure and domain information, and biomedical journal literature via PubMed. BLAST provides sequence similarity searches of GenBank and other sequence databases. Complete bimonthly releases and daily updates of GenBank database are available by FTP.
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View all literature mentionsCompany provides laboratories worldwide with analytical instruments and supplies, clinical and diagnostic testing services, consumables, applications and expertise in life sciences and applied chemical markets.
View all literature mentionsSoftware package for differential gene expression analysis based on the negative binomial distribution. Used for analyzing RNA-seq data for differential analysis of count data, using shrinkage estimation for dispersions and fold changes to improve stability and interpretability of estimates.
View all literature mentionsProvides digital infrastructure, data analytics and decision support tools to help in diagnosis, treatment and monitoring of patients.
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