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Single-cell profiling reveals the intratumor heterogeneity and immunosuppressive microenvironment in cervical adenocarcinoma.

Yang Peng | Jing Yang | Jixing Ao | Yilin Li | Jia Shen | Xiang He | Dihong Tang | Chaonan Chu | Congrong Liu | Liang Weng
eLife | 2025

Cervical adenocarcinoma (ADC) is more aggressive compared to other types of cervical cancer (CC), such as squamous cell carcinoma (SCC). The tumor immune microenvironment (TIME) and tumor heterogeneity are recognized as pivotal factors in cancer progression and therapy. However, the disparities in TIME and heterogeneity between ADC and SCC are poorly understood.

Pubmed ID: 40066698

Research resources used in this publication

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Associated grants

  • Agency: National Natural Science Foundation of China,
    Id: 82002753
  • Agency: Natural Science Foundation of Hunan Province,
    Id: 2021JJ40324
  • Agency: National Natural Science Foundation of China,
    Id: 82072882
  • Agency: Natural Science Foundation of Hunan Province,
    Id: 2022JJ70103
  • Agency: National Natural Science Foundation of China,
    Id: 81500475

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Monocle2 (tool)

RRID:SCR_016339

Software package for analyzing single cell gene expression, classifying and counting cells, performing differential expression analysis between subpopulations of cells, and reconstructing cellular trajcectories. Works well with very large single-cell RNA-Seq experiments containing tens of thousands of cells or more. Used in computational analysis of gene expression data in single cell gene expression studies to profile transcriptional regulation in complex biological processes and highly heterogeneous cell populations.

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CellMarker (tool)

RRID:SCR_018503

Database provides cell markers for various cell types in tissues of human and mouse. Manually curated resource of cell markers in human and mouse. Provides user-friendly interface for browsing, searching and downloading markers of diverse cell types of different tissues. Summarized marker prevalence in each cell type is graphically presented.

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10x Genomics (tool)

RRID:SCR_023672

American biotechnology company that designs and manufactures gene sequencing technology used in scientific research.

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