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Chaihuang Qingyi Huoxue granule ameliorates severe acute pancreatitis by modulating gut microbiota and repairing the intestinal mucosal barrier.

Xiaobin Zhang | Xusen Zeng | Wen Guo | Xin Zhou | Yi Zhang | Mingyun Tang | Juan Fu | Yuqing Deng | Xin Liang | Long Zhao | Zhi Li | Tiangang Wang | Li Li | Guohui Xiao
Frontiers in cellular and infection microbiology | 2025

During severe acute pancreatitis (SAP), damage to the intestinal mucosal barrier and translocation of intestinal pathogenic bacteria are key mechanisms that accelerate the disease progression of SAP. Chaihuang Qingyi Huoxue Granule (CH) is a herbal formula used in the clinical treatment of SAP. This study aims to investigate the role of CH in regulating gut microbiota and intestinal mucosal barrier in SAP rats.

Pubmed ID: 40041150

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