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Lipid droplets (LDs) are dynamic cytoplasmic lipid-storing organelles that play a pivotal role in maintaining cellular energy balance, lipid homeostasis, and metabolic signaling. Dysregulation of lipid metabolism, particularly excessive lipogenesis, contributes to the abnormal accumulation of LDs in the nervous system, which is associated with several neurodegenerative diseases. Circular RNAs (circRNAs) are a new class of non-coding and regulatory RNAs that are widely expressed in eukaryotes. However, only a subset has been functionally characterized. Here, we identified and functionally characterized a new circular RNA circbabo(5,6,7,8S) that regulates lipogenesis and neuronal integrity in Drosophila melanogaster.
Pubmed ID: 40038674
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Software performing alignment of high-throughput RNA-seq data. Aligns RNA-seq reads to reference genome using uncompressed suffix arrays.
View all literature mentionsSoftware repository for R packages related to analysis and comprehension of high throughput genomic data. Uses separate set of commands for installation of packages. Software project based on R programming language that provides tools for analysis and comprehension of high throughput genomic data.
View all literature mentionsDatabase of Drosophila genetic and genomic information with information about stock collections and fly genetic tools. Gene Ontology (GO) terms are used to describe three attributes of wild-type gene products: their molecular function, the biological processes in which they play a role, and their subcellular location. Additionally, FlyBase accepts data submissions. FlyBase can be searched for genes, alleles, aberrations and other genetic objects, phenotypes, sequences, stocks, images and movies, controlled terms, and Drosophila researchers using the tools available from the "Tools" drop-down menu in the Navigation bar.
View all literature mentionsBioconductor software package for Empirical analysis of Digital Gene Expression data in R. Used for differential expression analysis of RNA-seq and digital gene expression data with biological replication.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-bmm.EGFP}2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] v[1]; P{y[+t7.7] v[+t1.8]=TRiP.HMS02033}attP40 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[67c23]; P{w[+mC]=UAS-babo.Q302D}3 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] v[1]; P{y[+t7.7] v[+t1.8]=TRiP.HMS02033}attP40 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[67c23]; P{w[+mC]=UAS-babo.Q302D}3 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-bmm.EGFP}2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; wg[Sp-1]/CyO, P{w[+mC]=ActGFP}JMR1; SREBP[189]/TM6B, Tb[+] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; wg[Sp-1]/CyO, P{w[+mC]=ActGFP}JMR1; SREBP[189]/TM6B, Tb[+] from BDSC.
View all literature mentions