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Comprehensive analysis of scRNA-seq and bulk RNA-seq reveals the non-cardiomyocytes heterogeneity and novel cell populations in dilated cardiomyopathy.

Siyu He | Chunyu Li | Mingxin Lu | Fang Lin | Sangyu Hu | Junfang Zhang | Luying Peng | Li Li
Journal of translational medicine | 2025

Dilated cardiomyopathy (DCM) is one of the most common causes of heart failure. Infiltration and alterations in non-cardiomyocytes of the human heart involve crucially in the occurrence of DCM and associated immunotherapeutic approaches.

Pubmed ID: 39762897

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Associated grants

  • Agency: Innovative Research Group Project of the National Natural Science Foundation of China,
    Id: 82070270

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This is a list of tools and resources that we have found mentioned in this publication.


CytoTRACE (tool)

RRID:SCR_022828

Software tool that predicts differentiation state of cells from single cell RNA sequencing data. Used for predicting differentiation states from scRNA-seq data.

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FerrDb (tool)

RRID:SCR_026852

Manually curated database of ferroptosis regulators and ferroptosis-disease associations. There are two secondary categories of ferroptosis regulators: (1) genes and (2) substances. Gene regulators include driver, suppressor, marker, and unclassified regulator. Substances cover range of chemical entities, including pure substances (e.g., iron, erastin) and mixtures (e.g., herbal extracts). Substance regulators include inducers and inhibitors. FerrDb V2 is updated database.

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