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Didang Tang alleviates neuronal ferroptosis after intracerebral hemorrhage by modulating the PERK/eIF2α/ATF4/CHOP/GPX4 signaling pathway.

Jing Lu | Hanying Xu | Li Li | Xiaolei Tang | Ying Zhang | Dongmei Zhang | Peng Xu | Liwei Sun | Jian Wang
Frontiers in pharmacology | 2024

Ferroptosis is a crucial process contributing to neuronal damage following intracerebral hemorrhage (ICH). Didang Tang (DDT), a traditional therapeutic, has been used clinically to manage ICH for many years, yet the molecular mechanisms by which by DDT protects neurons from ferroptosis after ICH remain elusive.

Pubmed ID: 39525631

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