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Phosphorylation of RelA/p65 Ser536 inhibits the progression and metastasis of hepatocellular carcinoma by mediating cytoplasmic retention of NF-κB p65.

Wentao Zuo | Haoyang Ma | Jianghui Bi | Tiaolan Li | Yifeng Mo | Shiyu Yu | Jia Wang | Beiqing Li | Jinfeng Huang | Yongwen Li | Li Li
Gastroenterology report | 2024

Intrahepatic and extrahepatic metastases contribute to the high recurrence rate and mortality of hepatocellular carcinoma (HCC). Constitutive activation of nuclear factor-κB (NF-κB) is a crucial feature of HCC. NF-κB p65 (p50-p65) is the most common dimeric form. Ser536 acts as an essential phosphorylation site of RelA/p65. However, the effect of RelA/p65 Ser536 phosphorylation on progression and metastases during intermediate and advanced HCC has not been reported.

Pubmed ID: 39498383

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Cell Signaling Technology (tool)

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