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Exosomal circPOLQ promotes macrophage M2 polarization via activating IL-10/STAT3 axis in a colorectal cancer model.

Zhenqiang Sun | Yanxin Xu | Bo Shao | Pengyuan Dang | Shengyun Hu | Haifeng Sun | Chen Chen | Chaoguan Wang | Jinbo Liu | Yang Liu | Junhong Hu
Journal for immunotherapy of cancer | 2024

Accumulating evidence demonstrates that an increased tumor-associated macrophage abundance is often associated with poor prognosis in colorectal cancer (CRC). The mechanism underlying the effect of tumor-derived exosomes on M2 macrophage polarization remains elusive.

Pubmed ID: 38782541

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