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Unveiling the emerging role of curcumin to alleviate ochratoxin A-induced muscle toxicity in grass carp (Ctenopharyngodon idella): in vitro and in vivo studies.

Piao Zhao | Lin Feng | Weidan Jiang | Pei Wu | Yang Liu | Hongmei Ren | Xiaowan Jin | Lu Zhang | Haifeng Mi | Xiaoqiu Zhou
Journal of animal science and biotechnology | 2024

Ochratoxin A (OTA), a globally abundant and extremely hazardous pollutant, is a significant source of contamination in aquafeeds and is responsible for severe food pollution. The developmental toxicity of OTA and the potential relieving strategy of natural products remain unclear. This study screened the substance curcumin (Cur), which had the best effect in alleviating OTA inhibition of myoblast proliferation, from 96 natural products and investigated its effect and mechanism in reducing OTA myotoxicity in vivo and in vitro.

Pubmed ID: 38734645

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Associated grants

  • Agency: the earmarked fund for CARS,
    Id: CARS-45
  • Agency: National Natural Science Foundation of China for Outstanding Youth Science Foundation,
    Id: 31922086
  • Agency: the Young Top-Notch Talent Support Program, and the 111 project,
    Id: D17015

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DSHB (tool)

RRID:SCR_013527

An antibody supplier which banks and distributes hybridomas and monoclonal antibodies for use in research. The bank includes antibodies against targets such as GFP, transcription factors, stem cells, and human.

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