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Construction and applications of the EOMA spheroid model of Kaposiform hemangioendothelioma.

Yanan Li | Xinglong Zhu | Li Li | Chunjuan Bao | Qin Liu | Ning Zhang | Ziyan He | Yi Ji | Ji Bao
Journal of biological engineering | 2024

Kaposiform hemangioendothelioma (KHE) is a rare intermediate vascular tumor with unclear pathogenesis. Recently, three dimensional (3D) cell spheroids and organoids have played an indispensable role in the study of many diseases, such as infantile hemangioma and non-involuting congenital hemangiomas. However, few research on KHE are based on the 3D model. This study aims to evaluate the 3D superiority, the similarity with KHE and the ability of drug evaluation of EOMA spheroids as an in vitro 3D KHE model.

Pubmed ID: 38486263

Associated grants

  • Agency: The Key Project in the Science & Technology Program of Sichuan Province,
    Id: 2022NSFSC1480
  • Agency: The Key Project in the Science & Technology Program of Sichuan Province,
    Id: 2022YFS0233
  • Agency: Post-Doctor Research Project, West China Hospital, Sichuan University,
    Id: 2023HXBH056
  • Agency: The National Natural Science Foundation of China,
    Id: 82273556
  • Agency: The National Natural Science Foundation of China,
    Id: 82070640
  • Agency: The 1.3.5 project for disciplines of excellence, West China Hospital Sichuan University,
    Id: ZYJC21014

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