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Identification of gene biomarkers for brain diseases via multi-network topological semantics extraction and graph convolutional network.

Ping Zhang | Weihan Zhang | Weicheng Sun | Jinsheng Xu | Hua Hu | Lei Wang | Leon Wong
BMC genomics | 2024

Brain diseases pose a significant threat to human health, and various network-based methods have been proposed for identifying gene biomarkers associated with these diseases. However, the brain is a complex system, and extracting topological semantics from different brain networks is necessary yet challenging to identify pathogenic genes for brain diseases.

Pubmed ID: 38350848

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None found

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Associated grants

  • Agency: Guangxi Science and Technology Base and Talent Special Project,
    Id: 2021AC19394 and 2021AC19354
  • Agency: Guangxi Science and Technology Base and Talent Special Project,
    Id: 2021AC19394 and 2021AC19354
  • Agency: Guangxi Science and Technology Base and Talent Special Project,
    Id: 2021AC19394 and 2021AC19354
  • Agency: Natural Science Foundation of Guangxi,
    Id: 2022JJD170019
  • Agency: Natural Science Foundation of Guangxi,
    Id: 2022JJD170019
  • Agency: Natural Science Foundation of Guangxi,
    Id: 2022JJD170019
  • Agency: Guangxi Postdoctoral Special Funding Project,
    Id: Leon Wong
  • Agency: Guangxi Postdoctoral Special Funding Project,
    Id: Leon Wong
  • Agency: STI 2030-Major Projects,
    Id: 2021ZD0200403
  • Agency: STI 2030-Major Projects,
    Id: 2021ZD0200403
  • Agency: National Natural Science Foundation of China,
    Id: 62172355
  • Agency: National Natural Science Foundation of China,
    Id: 62172355

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DisGeNET (tool)

RRID:SCR_006178

Database and discovery platform containing publicly available collections of genes and variants associated to human diseases. Integrates data from curated repositories, GWAS catalogues, animal models and scientific literature.

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