Searching the Resource Information Network
Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.
Generating specific, robust protective responses to different bacteria is vital for animal survival. Here, we address the role of transforming growth factor β (TGF-β) member DBL-1 in regulating signature host defense responses in Caenorhabditis elegans to human opportunistic Gram-negative and Gram-positive pathogens. Canonical DBL-1 signaling is required to suppress avoidance behavior in response to Gram-negative, but not Gram-positive bacteria. We propose that in the absence of DBL-1, animals perceive some bacteria as more harmful. Animals activate DBL-1 pathway activity in response to Gram-negative bacteria and strongly repress it in response to select Gram-positive bacteria, demonstrating bacteria-responsive regulation of DBL-1 signaling. DBL-1 signaling differentially regulates expression of target innate immunity genes depending on the bacterial exposure. These findings highlight a central role for TGF-β in tailoring a suite of bacteria-specific host defenses.
Pubmed ID: 37750680
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Global nonprofit biological resource center (BRC) and research organization that provides biological products, technical services and educational programs to private industry, government and academic organizations. Its mission is to acquire, authenticate, preserve, develop and distribute biological materials, information, technology, intellectual property and standards for the advancement and application of scientific knowledge. The primary purpose of ATCC is to use its resources and experience as a BRC to become the world leader in standard biological reference materials management, intellectual property resource management and translational research as applied to biomaterial development, standardization and certification. ATCC characterizes cell lines, bacteria, viruses, fungi and protozoa, as well as develops and evaluates assays and techniques for validating research resources and preserving and distributing biological materials to the public and private sector research communities.
View all literature mentionsCenter that acquires, maintains, and distributes genetic stocks and information about stocks of the small free-living nematode Caenorhabditis elegans for use by investigators initiating or continuing research on this genetic model organism. A searchable strain database, general information about C. elegans, and links to key Web sites of use to scientists, including WormBase, WormAtlas, and WormBook are available.
View all literature mentionsCaenorhabditis elegans with name sma-4(e729) III. from WB.
View all literature mentionsCaenorhabditis elegans with name sma-3(e491) III. from WB.
View all literature mentionsEscherichia coli with name E. coli. from WB.
View all literature mentionsCaenorhabditis elegans with name sma-4(jj278) III. from WB.
View all literature mentionsCaenorhabditis elegans with name pha-1(e2123) III; denEx21. from WB.
View all literature mentionsCaenorhabditis elegans with name unc-119(ed3) III; eEx650. from WB.
View all literature mentionsCaenorhabditis elegans with name pha-1(e2123) III; denEx17. from WB.
View all literature mentionsCaenorhabditis elegans with name dbl-1(nk3) V. from WB.
View all literature mentionsCaenorhabditis elegans with name sma-2(e502) III. from WB.
View all literature mentionsCaenorhabditis elegans with name jjIs2277. from WB.
View all literature mentionsCaenorhabditis elegans with name pha-1(e2123) III; denEx26. from WB.
View all literature mentionsCaenorhabditis elegans with name agIs6. from WB.
View all literature mentionsCaenorhabditis elegans with name Caenorhabditis elegans wild isolate. from WB.
View all literature mentions