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Genetically determined circulating resistin concentrations and risk of colorectal cancer: a two-sample Mendelian randomization study.

Thu Thi Pham | Katharina Nimptsch | Nikos Papadimitriou | Krasimira Aleksandrova | Mazda Jenab | Marc J Gunter | Loic Le Marchand | Li Li | Brigid M Lynch | Sergi Castellví-Bel | Amanda I Phipps | Stephanie L Schmit | Hermann Brenner | Shuji Ogino | Edward Giovannucci | Tobias Pischon
Journal of cancer research and clinical oncology | 2023

Resistin, a novel pro-inflammatory protein implicated in inflammatory processes, has been suggested to play a role in colorectal development. However, evidence from observational studies has been inconsistent. Mendelian randomization may be a complementary method to examine this association.

Pubmed ID: 37599317

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FinnGen (tool)

RRID:SCR_022254

Public private partnership combining genotype data from Finnish biobanks and digital health record data from Finnish health registries. Provides opportunity to study genetic variation in relation to disease trajectories in isolated population.

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