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Causal Role for Neutrophil Elastase in Thoracic Aortic Dissection in Mice.

Mei Yang | Xinmiao Zhou | Stuart W A Pearce | Zhisheng Yang | Qishan Chen | Kaiyuan Niu | Chenxin Liu | Jun Luo | Dan Li | Yue Shao | Cheng Zhang | Dan Chen | Qingchen Wu | Pedro R Cutillas | Lin Zhao | Qingzhong Xiao | Li Zhang
Arteriosclerosis, thrombosis, and vascular biology | 2023

Thoracic aortic dissection (TAD) is a life-threatening aortic disease without effective medical treatment. Increasing evidence has suggested a role for NE (neutrophil elastase) in vascular diseases. In this study, we aimed at investigating a causal role for NE in TAD and exploring the molecular mechanisms involved.

Pubmed ID: 37589142

Research resources used in this publication

None found

Antibodies used in this publication

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Associated grants

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ATCC (tool)

RRID:SCR_001672

Global nonprofit biological resource center (BRC) and research organization that provides biological products, technical services and educational programs to private industry, government and academic organizations. Its mission is to acquire, authenticate, preserve, develop and distribute biological materials, information, technology, intellectual property and standards for the advancement and application of scientific knowledge. The primary purpose of ATCC is to use its resources and experience as a BRC to become the world leader in standard biological reference materials management, intellectual property resource management and translational research as applied to biomaterial development, standardization and certification. ATCC characterizes cell lines, bacteria, viruses, fungi and protozoa, as well as develops and evaluates assays and techniques for validating research resources and preserving and distributing biological materials to the public and private sector research communities.

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Promega (tool)

RRID:SCR_006724

An Antibody supplier

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Abcam (tool)

RRID:SCR_012931

A commercial antibody supplier which supplies primary and secondary antibodies, biochemicals, proteins, peptides, lysates, immunoassays and other kits.

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Primer Express (tool)

RRID:SCR_014326

Software that allows users to manually or automatically design custom primers and probes for gene quantitation and allelic discrimination (SNP) real-time PCR applications. It supports assays based on TaqMan and SYBR Green I dye chemistries.

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