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Comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice'.

Anne Sustar | John C Tuthill
eLife | 2023

Abrams et al. report that a simple dietary supplement is sufficient to induce appendage regeneration in jellyfish, fruit flies, and mice (Abrams et al., 2021). This conclusion is surprising because it was previously thought that flies and mice lack the capacity for regeneration after injury. We replicated the Drosophila experiments of Abrams et al. but did not observe any instances of leg regeneration. We also conclude that the "white blob" observed at the amputation site by Abrams et al. consists of bacteria and is not regenerated tissue.

Pubmed ID: 37347531

Associated grants

  • Agency: NIH HHS, United States
    Id: U19NS104655
  • Agency: NIH HHS, United States
    Id: S10 OD016240
  • Agency: NINDS NIH HHS, United States
    Id: R01 NS102333
  • Agency: NIH HHS, United States
    Id: P40 OD018537
  • Agency: NIH HHS, United States
    Id: R01NS102333
  • Agency: NINDS NIH HHS, United States
    Id: U19 NS104655

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