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Publication

A neuron-specific Isca1 knockout rat developments multiple mitochondrial dysfunction syndromes.

Hanxuan Sheng | Dan Lu | Xiaolong Qi | Yahao Ling | Jing Li | Xu Zhang | Wei Dong | Wei Chen | Shan Gao | Xiang Gao | Li Zhang | Lianfeng Zhang
Animal models and experimental medicine | 2023

Multiple mitochondrial dysfunction syndromes (MMDS) are rare mitochondrial diseases caused by mutation of mitochondrial iron-sulfur cluster synthesis proteins. This study established a rat model simulating MMDS5 disease in the nervous system to investigate its pathological features and neuronal death.

Pubmed ID: 37140997

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