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Antitumor effect of CAR-T cells targeting transmembrane tumor necrosis factor alpha combined with PD-1 mAb on breast cancers.

Hongping Ba | Zigang Dai | Zunyue Zhang | Peng Zhang | Bingjiao Yin | Jing Wang | Zhuoya Li | Xiaoxi Zhou
Journal for immunotherapy of cancer | 2023

Our previous study showed that transmembrane tumor necrosis factor alpha (tmTNF-α) is overexpressed in primary breast cancers including triple-negative breast cancers (TNBCs). Chimeric antigen receptor engineered-T (CAR-T) cells have been successfully used mainly in B-cell malignancies.

Pubmed ID: 36720496

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PeproTech (tool)

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RRID:CVCL_0063

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