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Determination of critical concentration for drug susceptibility testing of Mycobacterium tuberculosis against para-aminosalicylic acid with clinical isolates with thyA, folC and dfrA mutations.

Wei Wang | Shanshan Li | Qiping Ge | Haiping Guo | Yuanyuan Shang | Weicong Ren | Yufeng Wang | Zhongtan Xue | Jie Lu | Yu Pang
Annals of clinical microbiology and antimicrobials | 2022

Accurate determination of antimicrobial resistance profiles is of great importance to formulate optimal regimens against multidrug-resistant tuberculosis (MDR-TB). Although para-aminosalicylic acid (PAS) has been widely used clinically, the reliable testing methods for PAS susceptibility were not established. Herein, we aimed to establish critical test concentration for PAS on the Mycobacterial Growth Indicator Tube (MGIT) 960 in our laboratory settings.

Pubmed ID: 36335391

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Associated grants

  • Agency: the Capital's Funds for Health Improvement and Research,
    Id: 2020-1-1041
  • Agency: Beijing Hospitals Authority Ascent Plan,
    Id: DFL20191601
  • Agency: Beijing Hospitals Authority Clinical Medicine Development of Special Funding,
    Id: ZYLX202122

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SWISS-MODEL (tool)

RRID:SCR_018123

Software tool as fully automated protein structure homology modeling server, accessible via ExPASy web server, or from program DeepView Swiss Pdb-Viewer. Structural bioinformatics web-server dedicated to homology modeling of 3D protein structures. Used to make protein modelling accessible to all biochemists and molecular biologists.

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