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Integrated System for On-Site Rapid and Safe Screening of COVID-19.

Dongheyu Zhang | Yuntao Guo | Liyang Zhang | Yao Wang | Siqi Peng | Simeng Duan | Lin Geng | Xiao Zhang | Wei Wang | Mengjie Yang | Guizhen Wu | Jiayi Chen | Zihao Feng | Xinyuan Wang | Yue Wu | Haotian Jiang | Qikang Zhang | Jingjun Sun | Shenwei Li | Yuping He | Meng Xiao | Yingchun Xu | Hongqiu Wang | Peipei Liu | Qun Zhou | Haiyun Luo
Analytical chemistry | 2022

Since the outbreak of coronavirus disease 2019 (COVID-19), the epidemic has been spreading around the world for more than 2 years. Rapid, safe, and on-site detection methods of COVID-19 are in urgent demand for the control of the epidemic. Here, we established an integrated system, which incorporates a machine-learning-based Fourier transform infrared spectroscopy technique for rapid COVID-19 screening and air-plasma-based disinfection modules to prevent potential secondary infections. A partial least-squares discrimination analysis and a convolutional neural network model were built using the collected infrared spectral dataset containing 857 training serum samples. Furthermore, the sensitivity, specificity, and prediction accuracy could all reach over 94% from the results of the field test regarding 968 blind testing samples. Additionally, the disinfection modules achieved an inactivation efficiency of 99.9% for surface and airborne tested bacteria. The proposed system is conducive and promising for point-of-care and on-site COVID-19 screening in the mass population.

Pubmed ID: 36184789

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MATLAB (tool)

RRID:SCR_001622

Multi paradigm numerical computing environment and fourth generation programming language developed by MathWorks. Allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user interfaces, and interfacing with programs written in other languages, including C, C++, Java, Fortran and Python. Used to explore and visualize ideas and collaborate across disciplines including signal and image processing, communications, control systems, and computational finance.

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