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Amphibian-derived peptide homodimer OA-GL17d promotes skin wound regeneration through the miR-663a/TGF-β1/Smad axis.

Yue Zhang | Ying Wang | Lin Zeng | Yixiang Liu | Huiling Sun | Shanshan Li | Siyu Wang | Longjun Shu | Naixin Liu | Saige Yin | Junsong Wang | Dan Ni | Yutong Wu | Ying Yang | Li He | Buliang Meng | Xinwang Yang
Burns & trauma | 2022

Amphibian-derived peptides exhibit considerable potential in the discovery and development of new therapeutic interventions for clinically challenging chronic skin wounds. MicroRNAs (miRNAs) are also considered promising targets for the development of effective therapies against skin wounds. However, further research in this field is anticipated. This study aims to identify and provide a new peptide drug candidate, as well as to explore the underlying miRNA mechanisms and possible miRNA drug target for skin wound healing.

Pubmed ID: 35832307

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