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Publication

PET/MR Imaging of a Lung Metastasis Model of Clear Cell Renal Cell Carcinoma with (2S,4R)-4-[18F]Fluoroglutamine.

Alyssa C Pollard | Vincenzo Paolillo | Bhasker Radaram | Sarah Qureshy | Li Li | Tapati Maity | Lei Wang | Md Nasir Uddin | Christopher G Wood | Jose A Karam | Mark D Pagel | David Piwnica-Worms | Steven W Millward | Natalie Wall Fowlkes | William Norton | Brian J Engel | Federica Pisaneschi | Niki M Zacharias
Molecular imaging and biology | 2022

Metabolic reprogramming plays an important role in the tumorigenesis of clear cell renal cell carcinoma (ccRCC). Currently, positron emission tomography (PET) reporters are not used clinically to visualize altered glutamine metabolism in ccRCC, which greatly hinders detection, staging, and real-time therapeutic assessment. We sought to determine if (2S,4R)-4-[18F]fluoroglutamine ([18F]FGln) could be used to interrogate altered glutamine metabolism in ccRCC lesions in the lung.

Pubmed ID: 35732988

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: P30 CA016672
  • Agency: NCI NIH HHS, United States
    Id: 1F31CA247338
  • Agency: NIH HHS, United States
    Id: S10 OD012304
  • Agency: NCI NIH HHS, United States
    Id: PA30CA016672

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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