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Publication

Purine-Induced IFN-γ Promotes Uric Acid Production by Upregulating Xanthine Oxidoreductase Expression.

Huanhuan Wang | Lingzhu Xie | Xuhong Song | Jing Wang | Xinyan Li | Zhike Lin | Ting Su | Bin Liang | Dongyang Huang
Frontiers in immunology | 2022

Limiting purine intake, inhibiting xanthine oxidoreductase (XOR) and inhibiting urate reabsorption in proximal tubule by uricosuric drugs, to reduce serum uric acid (UA) levels, are recognized treatments for gout. However, the mechanism of increased how XOR expression and activity in hyperuricemia and gout remains unclear. This study aims to explore whether exogenous purines are responsible for increased XOR expression and activity.

Pubmed ID: 35154100

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