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Upregulation of nuclear factor E2-related factor 2 (Nrf2) represses the replication of herpes simplex virus type 1.

Li Zhang | Jiao Wang | Zhan Wang | Ying Li | Hui Wang | Hongtu Liu
Virology journal | 2022

Nuclear factor E2-related factor 2 (Nrf2) is an important transcription factor which plays a pivotal role in detoxifying reactive oxygen species (ROS) and has been more recently shown to regulate inflammatory and antiviral responses. However, the role of Nrf2 in Herpes Simplex Virus type 1 (HSV-1) infection is still unclear. In this study, the interaction between the Nrf2 and HSV-1 replication was investigated.

Pubmed ID: 35101046

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HEp-2 (tool)

RRID:CVCL_1906

Cell line HEp-2 is a Cancer cell line with a species of origin Homo sapiens (Human)

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Vero (tool)

RRID:CVCL_0059

Cell line Vero is a Spontaneously immortalized cell line with a species of origin Chlorocebus sabaeus

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