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Epigenome-wide analysis of DNA methylation and coronary heart disease: a nested case-control study.

Jiahui Si | Songchun Yang | Dianjianyi Sun | Canqing Yu | Yu Guo | Yifei Lin | Iona Y Millwood | Robin G Walters | Ling Yang | Yiping Chen | Huaidong Du | Yujie Hua | Jingchao Liu | Junshi Chen | Zhengming Chen | Wei Chen | Jun Lv | Liming Liang | Liming Li | China Kadoorie Biobank Collaborative Group
eLife | 2021

Identifying environmentally responsive genetic loci where DNA methylation is associated with coronary heart disease (CHD) may reveal novel pathways or therapeutic targets for CHD. We conducted the first prospective epigenome-wide analysis of DNA methylation in relation to incident CHD in the Asian population.

Pubmed ID: 34515027

Additional research tools detected in this publication

None found

Antibodies used in this publication

None found

Associated grants

  • Agency: Wellcome Trust, United Kingdom
    Id: 202922/Z/16/Z
  • Agency: Wellcome Trust, United Kingdom
    Id: 212946/Z/18/Z
  • Agency: Medical Research Council, United Kingdom
    Id: MC_UU_12026/2
  • Agency: Medical Research Council, United Kingdom
    Id: MC_UU_00017/1
  • Agency: Medical Research Council, United Kingdom
    Id: MC_U137686851
  • Agency: Wellcome Trust, United Kingdom
    Id: 088158/Z/09/Z
  • Agency: Medical Research Council, United Kingdom
    Id: MC_PC_13049
  • Agency: Wellcome Trust, United Kingdom
  • Agency: Medical Research Council, United Kingdom
    Id: MC_PC_14135
  • Agency: Wellcome Trust, United Kingdom
    Id: 104085/Z/14/Z

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This is a list of tools and resources that we have found mentioned in this publication.


minfi (software resource)

RRID:SCR_012830

Software tools for analyzing and visualizing Illumina''s 450k array data.

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Weighted Gene Co-expression Network Analysis (software resource)

RRID:SCR_003302

Software R package for weighted correlation network analysis. WGCNA is also available as point-and-click application. Unfortunately this application is not maintained anymore. It is known to have compatibility problems with R-2.8.x and newer, and the methods it implements are not all state of the art.

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wateRmelon (software resource)

RRID:SCR_001296

Software package for Illumina 450 methylation array normalization and metrics including 15 flavors of betas and three performance metrics, with methods for objects produced by methylumi, minfi and IMA packages.

View all literature mentions

Stata (software resource)

RRID:SCR_012763

A Software resource for statistical analysis and presentation of graphics.

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