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Immune challenges demand the gearing up of basal hematopoiesis to combat infection. Little is known about how during development, this switch is achieved to take care of the insult. Here, we show that the hematopoietic niche of the larval lymph gland of Drosophila senses immune challenge and reacts to it quickly through the nuclear factor-κB (NF-κB), Relish, a component of the immune deficiency (Imd) pathway. During development, Relish is triggered by ecdysone signaling in the hematopoietic niche to maintain the blood progenitors. Loss of Relish causes an alteration in the cytoskeletal architecture of the niche cells in a Jun Kinase-dependent manner, resulting in the trapping of Hh implicated in progenitor maintenance. Notably, during infection, downregulation of Relish in the niche tilts the maintenance program toward precocious differentiation, thereby bolstering the cellular arm of the immune response.
Pubmed ID: 34292149
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Web tool for graphical illustrations for biological systems by BioRender. Used for articles and presentations. Collection of pre made icons and templates from life science fields for scientific illustrations. Customized icons possible on request.
View all literature mentionsServes Drosophila research community by collecting and distributing DNA clones and vectors; collecting and distributing Drosophila cell lines; developing and testing genomics technologies for use in Drosophila and assisting members of the research community in their use.
View all literature mentionsAn antibody supplier which banks and distributes hybridomas and monoclonal antibodies for use in research. The bank includes antibodies against targets such as GFP, transcription factors, stem cells, and human.
View all literature mentionsBiomaterial supply resource which collects, maintains, and distributes independent transgenic fly lines. Most of the 38,000 fly lines are RNAi lines, but VDRC also maintains a collection of enhancer-GAL4 driver lines. Nearly all lines are in duplicate. Users can search for the stocks or DNA constructs for the gene of interest by entering CG number, synonym, or Transformant ID.
View all literature mentionsThis monoclonal targets NimC1
View all literature mentionsThis unknown targets
View all literature mentionsThis monoclonal targets Phospho-Histone H3 (Ser10) (D2C8) XP Rabbit mAb (ylated)
View all literature mentionsThis monoclonal targets Cubitus interruptus (Ci) full length
View all literature mentionsThis monoclonal targets integrin betaPS (myospheroid)
View all literature mentionsThis monoclonal targets cadherin, DE- (extracellular domain)
View all literature mentionsThis monoclonal targets singed (fascin)
View all literature mentionsThis monoclonal targets hindsight: zinc-finger nuclear protein hindsight
View all literature mentionsThis monoclonal targets Human JAM2
View all literature mentionsThis monoclonal targets Mouse Drosophila Wingless protein
View all literature mentionsThis monoclonal targets Mouse Drosophila enabled
View all literature mentionsThis monoclonal targets ecdysone receptor (EcR common)
View all literature mentionsDrosophila melanogaster with name wg[l-12] cn[1] bw[1]/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.GL00408}attP40/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMS00844}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; TI{w[+mW.hs]=TI}PGRP-LB[Delta] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*] Tak1[2] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-FLAG-Rel.68}i21-B; TM2/TM6C, Sb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name wg[l-12] cn[1] bw[1]/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118] from BDSC.
View all literature mentionsDrosophila melanogaster with name P{w[+mC]=UAS-FLAG-Rel.68}1, w[*]; TM2/TM6C, Sb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mC]=UAS-EGFP-Clc}5/TM6B, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMS00070}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mC]=UAS-GFP.E2f1.1-230}32 P{w[+mC]=UAS-mRFP1.NLS.CycB.1-266}19/CyO, P{ry[+t7.2]=en1}wg[en11]; MKRS/TM6B, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.GL00408}attP40/CyO from BDSC.
View all literature mentionsSoftware package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
View all literature mentionsDrosophila melanogaster with name P{w[+mC]=UAS-FLAG-Rel.68}1, w[*]; TM2/TM6C, Sb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mC]=UAS-EGFP-Clc}5/TM6B, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118] P{w[+mC]=UAS-bsk.DN}2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118] P{w[+mC]=UAS-bsk.DN}2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mC]=UAS-GFP.E2f1.1-230}32 P{w[+mC]=UAS-mRFP1.NLS.CycB.1-266}19/CyO, P{ry[+t7.2]=en1}wg[en11]; MKRS/TM6B, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-FLAG-Rel.68}i21-B; TM2/TM6C, Sb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name P{w[+mC]=UAS-mCD8.mRFP.LG}28a, y[1] w[*] from BDSC.
View all literature mentionsDrosophila melanogaster with name P{w[+mC]=UAS-GMA}1, w[1118] from BDSC.
View all literature mentionsDrosophila melanogaster with name P{w[+mC]=UAS-Hep.Act}1, w[*]/FM6, w[*] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mC]=UAS-EcR.B1-DeltaC655.W650A}TP1-9 from BDSC.
View all literature mentionsDrosophila melanogaster with name P{w[+mC]=UAS-Hep.Act}1, w[*]/FM6, w[*] from BDSC.
View all literature mentionsSoftware for image processing, analysis, and editing. The software includes features such as touch capabilities, a customizable toolbar, 2D and 3D image merging, and Cloud access and options.
View all literature mentionsDrosophila melanogaster with name w[1118] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{y[+t7.7] w[+mC]=TRE-EGFP}attP16 from BDSC.
View all literature mentionsDrosophila melanogaster with name P{w[+mC]=UAS-mCD8.mRFP.LG}28a, y[1] w[*] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*] Tak1[2] from BDSC.
View all literature mentionsImaris provides range of capabilities for working with three dimensional images. Uses flexible editing and processing functions, such as interactive surface rendering and object slicing capabilities. And output to standard TIFF, Quicktime and AVI formats. Imaris accepts virtually all image formats that are used in confocal microscopy and many of those used in wide-field image acquisition.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mC]=UAS-EcR.B1-DeltaC655.W650A}TP1-9 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; TI{w[+mW.hs]=TI}PGRP-LB[Delta] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMS00844}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name P{w[+mC]=UAS-GMA}1, w[1118] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{y[+t7.7] w[+mC]=TRE-EGFP}attP16 from BDSC.
View all literature mentionsDrosophila melanogaster with name P{KK100935}VIE-260B from Flybase.
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