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LncRNA DNM3OS regulates GREM2 via miR-127-5p to suppress early chondrogenic differentiation of rat mesenchymal stem cells under hypoxic conditions.

Xiaozhong Zhou | Wangyang Xu | Yeyang Wang | Hui Zhang | Li Zhang | Chao Li | Shun Yao | Zixiang Huang | Lishan Huang | Dixin Luo
Cellular & molecular biology letters | 2021

Improved chondrogenic differentiation of mesenchymal stem cells (MSCs) by genetic regulation is a potential method for regenerating articular cartilage. MiR-127-5p has been reported to promote cartilage differentiation of rat bone marrow MSCs (rMSCs); however, the regulatory mechanisms underlying hypoxia-stimulated chondrogenic differentiation remain unknown.

Pubmed ID: 34049478

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