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FDG-PET in presymptomatic C9orf72 mutation carriers.

Karteek Popuri | Mirza Faisal Beg | Hyunwoo Lee | Rakesh Balachandar | Lei Wang | Vesna Sossi | Claudia Jacova | Matt Baker | Elham Shahinfard | Rosa Rademakers | Ian R A Mackenzie | Ging-Yuek R Hsiung
NeuroImage. Clinical | 2021

Our aim is to investigate patterns of brain glucose metabolism using fluorodeoxyglucose positron emission tomography (FDG-PET) in presymptomatic carriers of the C9orf72 repeat expansion to better understand the early preclinical stages of frontotemporal dementia (FTD).

Pubmed ID: 34049163

Research resources used in this publication

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Associated grants

  • Agency: NIA NIH HHS, United States
    Id: R01 AG055121

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FreeSurfer (tool)

RRID:SCR_001847

Open source software suite for processing and analyzing human brain MRI images. Used for reconstruction of brain cortical surface from structural MRI data, and overlay of functional MRI data onto reconstructed surface. Contains automatic structural imaging stream for processing cross sectional and longitudinal data. Provides anatomical analysis tools, including: representation of cortical surface between white and gray matter, representation of the pial surface, segmentation of white matter from rest of brain, skull stripping, B1 bias field correction, nonlinear registration of cortical surface of individual with stereotaxic atlas, labeling of regions of cortical surface, statistical analysis of group morphometry differences, and labeling of subcortical brain structures.Operating System: Linux, macOS.

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